A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity (Q30279239)

14 June 2017

A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity (English)

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14 June 2017

Orthoebolavirus zairense

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14

Lisa E Hensley

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14 June 2017

Lisa M Johansen

1

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14 June 2017

Lisa Evans DeWald

2

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14 June 2017

Charles J Shoemaker

3

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14 June 2017

Benjamin G Hoffstrom

4

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14 June 2017

Calli M Lear-Rooney

5

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14 June 2017

Andrea Stossel

6

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14 June 2017

Elizabeth Nelson

7

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14 June 2017

Sue E Delos

8

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14 June 2017

James A Simmons

9

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14 June 2017

Jill M Grenier

10

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14 June 2017

Laura T Pierce

11

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14 June 2017

Hassan Pajouhesh

12

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14 June 2017

Joseph Lehár

13

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14 June 2017

Pamela J Glass

15

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14 June 2017

Judith M White

16

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14 June 2017

Gene G Olinger

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14 June 2017

language of work or name

English

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publication date

1 June 2015

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Science Translational Medicine

14 June 2017

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14 June 2017

7

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14 June 2017

290

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14 June 2017

290ra89

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Pathogenesis of filoviral haemorrhagic fevers

14 June 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Post-exposure therapy of filovirus infections

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Systematic discovery of multicomponent therapeutics

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Drug repositioning: identifying and developing new uses for existing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

21 January 2018

New uses for old drugs

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Synergistic drug combinations tend to improve therapeutically relevant selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Filovirus entry: a novelty in the viral fusion world

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

A new player in the puzzle of filovirus entry

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Inhibition of dengue virus replication by mycophenolic acid and ribavirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Natural compounds inhibiting the replication of Porcine reproductive and respiratory syndrome virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Identification of novel functional inhibitors of acid sphingomyelinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Effects of charged drugs on the phase transition temperatures of phospholipid bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Cellular electropharmacology of amiodarone

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Epitopes involved in antibody-mediated protection from Ebola virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA5597

10.1126/SCITRANSLMED.AAA5597

21 January 2018

Identifiers

DOI

1 reference

14 June 2017

1 reference