How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation (Q30480541)

12 August 2017

How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation (English)

1 reference

12 August 2017

Viola Vogel

4

0 references

Klaus Schulten

series ordinal

3

object named as

Klaus Schulten

1 reference

12 August 2017

Eileen Puklin-Faucher

series ordinal

1

1 reference

PMCID

2064575

12 August 2017

Mu Gao

series ordinal

2

1 reference

PMCID

2064575

12 August 2017

language of work or name

English

0 references

publication date

1 October 2006

1 reference

12 August 2017

Journal of Cell Biology

1 reference

12 August 2017

175

1 reference

12 August 2017

2

1 reference

12 August 2017

349-360

1 reference

All-atom empirical potential for molecular modeling and dynamics studies of proteins

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Local force and geometry sensing regulate cell functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Scalable molecular dynamics with NAMD

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active state

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

A specific interface between integrin transmembrane helices and affinity for ligand

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Integrins in mechanotransduction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Mechanobiology and diseases of mechanotransduction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Adhesion-dependent cell mechanosensitivity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Structure of integrin alpha5beta1 in complex with fibronectin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

New insights into the structural basis of integrin activation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Integrins: bidirectional, allosteric signaling machines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Integrin activation and structural rearrangement

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Will the real integrin please stand up?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Crystal structure of the extracellular segment of integrin alpha Vbeta3

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Steered molecular dynamics and mechanical functions of proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

VMD: visual molecular dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation

20 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200602071

Protein domain movements: detection of rigid domains and visualization of hinges in comparisons of atomic coordinates.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064575

Two-step binding mechanism of fibrinogen to alpha IIb beta 3 integrin reconstituted into planar lipid bilayers

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17060501

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17060501

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200602071

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

2064575