Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice (Q30482976)

16 August 2017

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice (English)

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16 August 2017

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Manik C Ghosh

1

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16 August 2017

Wing-Hang Tong

2

1 reference

16 August 2017

Deliang Zhang

3

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16 August 2017

Hayden Ollivierre-Wilson

4

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16 August 2017

Anamika Singh

5

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16 August 2017

Murali C Krishna

6

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16 August 2017

James B Mitchell

7

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16 August 2017

Tracey A Rouault

8

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16 August 2017

language of work or name

English

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publication date

6 August 2008

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Proceedings of the National Academy of Sciences of the United States of America

16 August 2017

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16 August 2017

105

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16 August 2017

33

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16 August 2017

12028-12033

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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

The chemistry and biology of nitroxide compounds

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

20 June 2018

Brain iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

The role of iron regulatory proteins in mammalian iron homeostasis and disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Crystal structure of human iron regulatory protein 1 as cytosolic aconitase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Balancing acts: molecular control of mammalian iron metabolism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Iron regulatory proteins as NO signal transducers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Rapid responses to oxidative stress mediated by iron regulatory protein.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Synthetic analogs of the active sites of iron-sulfur proteins. VI. Spectral and redox characteristics of the tetranuclear clusters (Fe4S4(SR)4).2-.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

A low molecular weight antioxidant decreases weight and lowers tumor incidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Neuroprotection by the stable nitroxide 3-carbamoyl-proxyl during reperfusion in a rat model of transient focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Lost in translation: again, another failed neuroprotection trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805361105

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2497459

Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18685102

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0805361105

1 reference

16 August 2017

0 references

1 reference

16 August 2017

PubMed publication ID

18685102

1 reference