Biophysical mechanism of T-cell receptor triggering in a reconstituted system (Q30519567)

19 October 2017

Biophysical mechanism of T-cell receptor triggering in a reconstituted system (English)

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19 October 2017

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19 October 2017

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Ronald D Vale

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19 October 2017

language of work or name

English

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publication date

1 July 2012

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19 October 2017

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19 October 2017

487

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19 October 2017

7405

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19 October 2017

64-69

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describes a project that uses

19 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3393772/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Mechanisms for size-dependent protein segregation at immune synapses assessed with molecular rulers

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T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

20 June 2018

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Mechanisms for T cell receptor triggering

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ITAM-mediated signaling by the T-cell antigen receptor

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Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

20 June 2018

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

20 June 2018

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Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

20 June 2018

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

20 June 2018

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The kinetic-segregation model: TCR triggering and beyond

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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

20 June 2018

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Structural and kinetic basis for heightened immunogenicity of T cell vaccines

20 June 2018

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

20 June 2018

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Pattern formation during T-cell adhesion.

20 June 2018

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CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

20 June 2018

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CD45: a critical regulator of signaling thresholds in immune cells

20 June 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

20 June 2018

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Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse

20 June 2018

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Synaptic pattern formation during cellular recognition

20 June 2018

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A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

20 June 2018

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Three-dimensional segregation of supramolecular activation clusters in T cells

20 June 2018

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Making the T cell receptor go the distance: a topological view of T cell activation

20 June 2018

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The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

20 June 2018

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The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity

20 June 2018

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

20 June 2018

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https://api.crossref.org/works/10.1038%2FNATURE11220

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

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Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE11220

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

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Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22763440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22763440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE11220

1 reference

Dimensions Publication ID

19 October 2017

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1 reference

19 October 2017

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