Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. (Q30556712)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors (English)

1 reference

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28 February 2020

4

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28 February 2020

Don W. Cleveland

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Alain D Silk

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Lauren M Zasadil

2

1 reference

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28 February 2020

Andrew J Holland

3

1 reference

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28 February 2020

Beth A Weaver

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

language of work or name

English

0 references

publication date

16 October 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

28 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

110

1 reference

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28 February 2020

issue

44

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28 February 2020

page(s)

E4134-41

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

28 February 2020

cites work

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Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

20 June 2018

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20 June 2018

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Frequent aneuploidy among normal human hepatocytes

20 June 2018

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Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice

20 June 2018

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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

20 June 2018

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20 June 2018

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The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

20 June 2018

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

20 June 2018

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Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

20 June 2018

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Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

20 June 2018

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Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.

20 June 2018

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

20 June 2018

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A mechanism linking extra centrosomes to chromosomal instability

20 June 2018

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Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

20 June 2018

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Whole chromosome instability and cancer: a complex relationship

20 June 2018

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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

20 June 2018

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CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether

20 June 2018

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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

20 June 2018

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Cell death in development: shaping the embryo

20 June 2018

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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

20 June 2018

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KLF4, p21 and context-dependent opposing forces in cancer

20 June 2018

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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

20 June 2018

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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

20 June 2018

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Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

20 June 2018

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Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

20 June 2018

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

20 June 2018

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Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

20 June 2018

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20 June 2018

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CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice

20 June 2018

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20 June 2018

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20 June 2018

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CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

20 June 2018

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20 June 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

20 June 2018

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Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis.

20 June 2018

1 reference

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Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

20 June 2018

1 reference

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The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

20 June 2018

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10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin

20 June 2018

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Induction of apoptosis in fibroblasts by c-myc protein

20 June 2018

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Aneuploidy acts both oncogenically and as a tumor suppressor

20 June 2018

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CENP-E as an essential component of the mitotic checkpoint in vitro.

21 January 2018

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Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.

21 January 2018

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Microsatellite instability in colorectal cancer

21 January 2018

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

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Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability.

21 January 2018

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The human blastocyst: cell number, death and allocation during late preimplantation development in vitro

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24133140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24133140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1317042110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

24133140

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24133140%20AND%20SRC:MED&resulttype=core&format=json