Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations (Q30596172)

15 October 2017

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations (English)

1 reference

15 October 2017

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Christopher C. Miller

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Alexander J. Whitworth

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Vinay K Godena

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Nicholas Brookes-Hocking

2

1 reference

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6 June 2020

Annekathrin Moller

3

1 reference

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6 June 2020

Gary Shaw

4

1 reference

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6 June 2020

Matthew Oswald

5

1 reference

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6 June 2020

Rosa M Sancho

6

1 reference

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6 June 2020

language of work or name

English

0 references

publication date

15 October 2014

1 reference

15 October 2017

Nature Communications

1 reference

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6 June 2020

volume

5

1 reference

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6 June 2020

page(s)

5245

1 reference

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Creative Commons Attribution 4.0 International

6 June 2020

copyright license

start time

15 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4208097/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

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In vivo visualization of synaptic vesicles within Drosophila larval segmental axons

14 July 2018

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MEC-17 is an alpha-tubulin acetyltransferase

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

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Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

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HDAC6 regulates mitochondrial transport in hippocampal neurons

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

14 July 2018

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

14 July 2018

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14 July 2018

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Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

14 July 2018

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14 July 2018

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

14 July 2018

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Role of axonal transport in neurodegenerative diseases

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A Drosophila model for LRRK2-linked parkinsonism

14 July 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

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14 July 2018

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

14 July 2018

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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

14 July 2018

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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

14 July 2018

1 reference

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

14 July 2018

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

14 July 2018

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Visualization and quantification of mitochondrial dynamics in living animal cells.

14 July 2018

1 reference

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

14 July 2018

1 reference

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

14 July 2018

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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

14 July 2018

1 reference

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Microtubule acetylation promotes kinesin-1 binding and transport.

14 July 2018

1 reference

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Microtubule deacetylases, SirT2 and HDAC6, in the nervous system

14 July 2018

1 reference

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

14 July 2018

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

14 July 2018

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A common LRRK2 mutation in idiopathic Parkinson's disease

14 July 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

14 July 2018

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

14 July 2018

1 reference

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

14 July 2018

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Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Identification of novel isoform-selective inhibitors within class I histone deacetylases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

HDAC6 is a microtubule-associated deacetylase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208097

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

14 July 2018

1 reference

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Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegeneration

21 January 2018

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Direct binding of alpha-actinin enhances TRPP3 channel activity

21 January 2018

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Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6245

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6245

Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6245

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6245

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6245

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6245

21 January 2018

Identifiers

DOI

10.1038/NCOMMS6245

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 June 2020

ADS bibcode

2014NatCo...5.5245G

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

25316291

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25316291%20AND%20SRC:MED&resulttype=core&format=json