The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons (Q35119950)

6 August 2017

The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons (English)

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6 August 2017

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1

Jeong Sook Kim-Han

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6 August 2017

Jo Ann Antenor-Dorsey

series ordinal

2

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6 August 2017

Karen L O'Malley

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3

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6 August 2017

language of work or name

English

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publication date

1 May 2011

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6 August 2017

Journal of Neuroscience

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6 August 2017

31

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6 August 2017

19

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6 August 2017

7212-7221

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describes a project that uses

6 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3140916/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

9 July 2018

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Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation

9 July 2018

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Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons.

9 July 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

9 July 2018

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9 July 2018

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The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease

9 July 2018

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9 July 2018

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Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy

9 July 2018

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HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport

9 July 2018

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Imaging axonal transport of mitochondria

9 July 2018

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The Miro GTPases: at the heart of the mitochondrial transport machinery

9 July 2018

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Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

9 July 2018

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Cytosolic LC3 ratio as a quantitative index of macroautophagy

9 July 2018

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

9 July 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

9 July 2018

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Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease

9 July 2018

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Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons

9 July 2018

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9 July 2018

Nerve injury signaling

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Role of axonal transport in neurodegenerative diseases

9 July 2018

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Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation

9 July 2018

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Calcium, ageing, and neuronal vulnerability in Parkinson's disease

9 July 2018

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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

9 July 2018

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Mitochondrial bioenergetics and structural network organization

9 July 2018

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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

9 July 2018

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Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

9 July 2018

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Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light

9 July 2018

1 reference

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Nitric oxide and MPP+-induced hydroxyl radical generation

9 July 2018

1 reference

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A microfluidic culture platform for CNS axonal injury, regeneration and transport

9 July 2018

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MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview

9 July 2018

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Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration

9 July 2018

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

9 July 2018

1 reference

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Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

9 July 2018

1 reference

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Time-course of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson's disease

9 July 2018

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Axonal transport of membranous and nonmembranous cargoes: a unified perspective

9 July 2018

1 reference

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Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

9 July 2018

1 reference

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The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes.

9 July 2018

1 reference

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Axonal self-destruction and neurodegeneration

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Role of mitochondrial dysfunction and dopamine-dependent oxidative stress in amphetamine-induced toxicity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegeneration

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140916

The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

27 September 2018

1 reference

12 December 2020

Swimming against the tide: mobility of the microtubule-associated protein tau in neurons

1 reference

12 December 2020

Kinetic analysis of guanosine 5'-triphosphate hydrolysis associated with tubulin polymerization

1 reference

12 December 2020

Quantitative analysis of membrane potentials

1 reference

12 December 2020

MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels

1 reference

12 December 2020

10.1523/JNEUROSCI.0711-11.2011

Identifiers

DOI

1 reference

release_pzn7pyxtcnagbgvaxypxbp4gei

6 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pzn7pyxtcnagbgvaxypxbp4gei

24 November 2022

mapped directly with Wikidata item

PMCID

3140916

1 reference

6 August 2017

1 reference