Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk. (Q30776360)

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English	Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.	scientific article

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scholarly article

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10 March 2020

Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk (English)

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10 March 2020

pharmacokinetics

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based on heuristic

inferred from title

drug interaction

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Aleksandra Galetin

5

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10 March 2020

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Michael Gertz

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10 March 2020

Nikolaos Tsamandouras

2

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10 March 2020

Carolina Säll

3

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10 March 2020

J Brian Houston

4

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10 March 2020

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13 March 2014

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10 March 2020

Pharmaceutical Research

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10 March 2020

31

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10 March 2020

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10 March 2020

2367-2382

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10 March 2020

Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development

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Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology

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21 January 2018

Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction.

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21 January 2018

Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide

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21 January 2018

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

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Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

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Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

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21 January 2018

Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

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21 January 2018

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Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model

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21 January 2018

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

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21 January 2018

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.

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21 January 2018

Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

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21 January 2018

Resolving the distribution-metabolism interplay of eight OATP substrates in the standard clearance assay with suspended human cryopreserved hepatocytes.

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21 January 2018

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21 January 2018

Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension

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21 January 2018

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21 January 2018

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1.

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21 January 2018

Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

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21 January 2018

A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

1 reference

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21 January 2018

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

1 reference

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21 January 2018

The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide

1 reference

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21 January 2018

Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1333-3

21 January 2018

The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range

1 reference

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21 January 2018

Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin

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21 January 2018

Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes

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Applications of minimal physiologically-based pharmacokinetic models

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Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

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21 January 2018

The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo

1 reference

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21 January 2018

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

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21 January 2018

DAISY: a new software tool to test global identifiability of biological and physiological systems

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21 January 2018

Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

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21 January 2018

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

1 reference

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21 January 2018

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

1 reference

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21 January 2018

Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro

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21 January 2018

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

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21 January 2018

Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats

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21 January 2018

Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes

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21 January 2018

Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.

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So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics

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Single-dose pharmacokinetics of repaglinide in subjects with chronic liver disease.

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Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes

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21 January 2018

Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

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21 January 2018

Effect of the CYP2C8 Genotype on the Pharmacokinetics and Pharmacodynamics of Repaglinide

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12 December 2020

based on heuristic

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OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture

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12 December 2020

based on heuristic

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Bioavailability of repaglinide, a novel antidiabetic agent, administered orally in tablet or solution form or intravenously in healthy male volunteers.

1 reference

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12 December 2020

based on heuristic

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Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view

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12 December 2020

based on heuristic

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Area method for the estimation of partition coefficients for physiological pharmacokinetic models

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CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

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12 December 2020

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Absorption, metabolism and excretion of a single oral dose of (14)C-repaglinide during repaglinide multiple dosing

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12 December 2020

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Basic anatomical and physiological data for use in radiological protection: reference values. A report of age- and gender-related differences in the anatomical and physiological characteristics of reference individuals. ICRP Publication 89

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12 December 2020

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Identifiers

10.1007/S11095-014-1333-3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24623479%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24623479%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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