Hsp90 regulation of fibroblast activation in pulmonary fibrosis (Q30838920)

21 August 2017

Hsp90 regulation of fibroblast activation in pulmonary fibrosis (English)

1 reference

21 August 2017

1 reference

Anil G Jegga

9

0 references

author name string

Vishwaraj Sontake

1

1 reference

21 August 2017

Yunguan Wang

2

1 reference

21 August 2017

Rajesh K Kasam

3

1 reference

21 August 2017

Debora Sinner

4

1 reference

21 August 2017

Geereddy B Reddy

5

1 reference

21 August 2017

Anjaparavanda P Naren

6

1 reference

21 August 2017

Francis X McCormack

7

1 reference

21 August 2017

Eric S White

8

1 reference

21 August 2017

Satish K Madala

10

1 reference

21 August 2017

23 February 2017

1 reference

21 August 2017

1 reference

21 August 2017

2

1 reference

21 August 2017

e91454

1 reference

21 August 2017

4

1 reference

describes a project that uses

21 August 2017

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5313067

inferred from PubMed Central ID database lookup

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TGF-β: the master regulator of fibrosis

21 June 2018

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Mechanisms of Lung Fibrosis Resolution

21 June 2018

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p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung

21 June 2018

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

21 June 2018

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Fibrocytes Regulate Wilms Tumor 1-Positive Cell Accumulation in Severe Fibrotic Lung Disease

21 June 2018

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Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy.

21 June 2018

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21 June 2018

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Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration/Motility of Keloid Fibroblasts.

21 June 2018

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Regulation and function of the human HSP90AA1 gene

21 June 2018

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Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

21 June 2018

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limma powers differential expression analyses for RNA-sequencing and microarray studies

21 June 2018

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Identification and verification of Hsp90-beta as a potential serum biomarker for lung cancer

21 June 2018

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Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease.

21 June 2018

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Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

21 June 2018

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The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis

21 June 2018

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Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis.

21 June 2018

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Heat shock proteins in fibrosis and wound healing: good or evil?

21 June 2018

1 reference

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Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

21 June 2018

1 reference

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Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

21 June 2018

1 reference

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Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

21 June 2018

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Heat shock protein 90 inhibitors in non-small-cell lung cancer

21 June 2018

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Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease

21 June 2018

1 reference

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Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-α-induced pulmonary fibrosis

21 June 2018

1 reference

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Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report

21 June 2018

1 reference

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Role of IGF-1 pathway in lung fibroblast activation

21 June 2018

1 reference

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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

21 June 2018

1 reference

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Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives

21 June 2018

1 reference

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Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

21 June 2018

1 reference

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Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution

21 June 2018

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Molecular mechanisms in progressive idiopathic pulmonary fibrosis

21 June 2018

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The myofibroblast matrix: implications for tissue repair and fibrosis.

21 June 2018

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Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor.

21 June 2018

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Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients

21 June 2018

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Mechanisms of fibrosis: therapeutic translation for fibrotic disease

21 June 2018

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Effect of insulin-like growth factor blockade on hyperoxia-induced lung injury

21 June 2018

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Recent developments in myofibroblast biology: paradigms for connective tissue remodeling

21 June 2018

1 reference

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MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Myofibroblast differentiation and survival in fibrotic disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis

21 June 2018

1 reference

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Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Quantitative assessment of macrophage functions in repair and fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Targeting heat shock proteins in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Signaling pathways in the epithelial origins of pulmonary fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Targeting the dynamic HSP90 complex in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

21 June 2018

1 reference

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Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

TGF-beta and fibrosis in different organs - molecular pathway imprints

21 June 2018

1 reference

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ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

21 June 2018

1 reference

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Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Critical regulation of TGFbeta signaling by Hsp90

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses.

21 June 2018

1 reference

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The myofibroblast: one function, multiple origins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

NCBI GEO: mining tens of millions of expression profiles--database and tools update

21 June 2018

1 reference

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Structure and mechanism of the Hsp90 molecular chaperone machinery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

21 June 2018

Fibroblasts in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Mechanisms of pulmonary fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Cytoscape: a software environment for integrated models of biomolecular interaction networks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Heat-shock protein 90, a chaperone for folding and regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Rho GTPases and cell migration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

21 June 2018

TGF-beta and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Hsp90 & Co. - a holding for folding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Identification of citrullinated hsp90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

TGF-beta1 induces progressive pleural scarring and subpleural fibrosis

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5313067

American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28239659

12 December 2020

inferred from PubMed ID database lookup

The Hsp90 ensemble: coordinated Hsp90-cochaperone complexes regulate diverse cellular processes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28239659

12 December 2020

inferred from PubMed ID database lookup

Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28239659

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI.INSIGHT.91454

1 reference

21 August 2017

1 reference

21 August 2017

1 reference