Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries (Q30993615)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26371303%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries (English)

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24 February 2020

1 reference

1 reference

3

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24 February 2020

author name string

Kenji L Kurita

series ordinal

1

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24 February 2020

Emerson Glassey

series ordinal

2

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24 February 2020

language of work or name

English

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publication date

14 September 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26371303%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

24 February 2020

published in

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24 February 2020

volume

112

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24 February 2020

issue

39

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24 February 2020

page(s)

11999-12004

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Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species

24 February 2020

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A roadmap for natural product discovery based on large-scale genomics and metabolomics

21 June 2018

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Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters

21 June 2018

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A screening pattern recognition method finds new and divergent targets for drugs and natural products

21 June 2018

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Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products.

21 June 2018

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Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa.

21 June 2018

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21 June 2018

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21 June 2018

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High-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products.

21 June 2018

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Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells

21 June 2018

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Mechanism of action-based classification of antibiotics using high-content bacterial image analysis

21 June 2018

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Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays

21 June 2018

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"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening

21 June 2018

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Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics.

21 June 2018

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Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.

21 June 2018

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Mass spectral molecular networking of living microbial colonies

21 June 2018

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Microbial strain prioritization using metabolomics tools for the discovery of natural products.

21 June 2018

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Natural products as sources of new drugs over the 30 years from 1981 to 2010

21 June 2018

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Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

21 June 2018

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The garden of antimicrobial delights

21 June 2018

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21 June 2018

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Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

21 June 2018

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Natural products as a robust source of new drugs and drug leads: past successes and present day issues

21 June 2018

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Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity

21 June 2018

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

21 June 2018

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Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase

21 June 2018

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Dereplication of microbial natural products by LC-DAD-TOFMS.

21 June 2018

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Explorative solid-phase extraction (E-SPE) for accelerated microbial natural product discovery, dereplication, and purification.

21 January 2018

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Multidimensional drug profiling by automated microscopy.

21 January 2018

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Highly accurate chemical formula prediction tool utilizing high-resolution mass spectra, MS/MS fragmentation, heuristic rules, and isotope pattern matching.

21 January 2018

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A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1507743112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26371303%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

0 references

1 reference

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24 February 2020

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