Stability of the core domain of p53: insights from computer simulations (Q33322204)

25 July 2017

Stability of the core domain of p53: insights from computer simulations (English)

1 reference

25 July 2017

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1

1 reference

25 July 2017

Derek John Smith

2

1 reference

PubMed ID

18315848

25 July 2017

Chandra Verma

series ordinal

3

1 reference

25 July 2017

1 January 2008

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25 July 2017

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25 July 2017

9 Suppl 1

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25 July 2017

S17

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2105-9-s1-s17

25 July 2017

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Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

14 July 2018

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Allosteric transitions in the chaperonin GroEL are captured by a dominant normal mode that is most robust to sequence variations.

14 July 2018

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Structure-function-rescue: the diverse nature of common p53 cancer mutants

14 July 2018

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14 July 2018

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p53 in health and disease

14 July 2018

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Structural Rigidity of a Large Cavity-containing Protein Revealed by High-pressure Crystallography

14 July 2018

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A consensus view of protein dynamics

14 July 2018

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p53 and p73 display common and distinct requirements for sequence specific binding to DNA

14 July 2018

1 reference

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14 July 2018

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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

14 July 2018

1 reference

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Structure of the p53 core domain dimer bound to DNA.

14 July 2018

1 reference

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Solution structure of p53 core domain: structural basis for its instability

14 July 2018

1 reference

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The Amber biomolecular simulation programs

14 July 2018

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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

14 July 2018

1 reference

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Protein stability and ligand binding: new paradigms from in-silico experiments

14 July 2018

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Characterization of the denaturation of human alpha-lactalbumin in urea by molecular dynamics simulations

14 July 2018

1 reference

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Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

14 July 2018

1 reference

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Live or let die: the cell's response to p53

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

14 July 2018

1 reference

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A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

14 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Collective protein dynamics in relation to function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

In vitro evolution of thermostable p53 variants

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structural aspects of the p53 protein in relation to gene evolution: a second look.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

New insights into p53 function from structural studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Comparative protein modelling by satisfaction of spatial restraints

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Essential dynamics of proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Role of cysteine residues in regulation of p53 function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structural basis of DNA recognition by p53 tetramers.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Mutational analysis of the p53 core domain L1 loop.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Comparison of the human and worm p53 structures suggests a way for enhancing stability.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Attempts to delineate the relative contributions of changes in hydrophobicity and packing to changes in stability of ribonuclease S mutants.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Replacement of staphylococcal nuclease hydrophobic core residues with those from thermophilic homologues indicates packing is improved in some thermostable proteins

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

The IARC TP53 database: new online mutation analysis and recommendations to users

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Thorough Validation of Protein Normal Mode Analysis: A Comparative Study with Essential Dynamics

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Effect of Zn2+on DNA Recognition and Stability of the p53 DNA-Binding Domain†

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2259418

Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18315848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hydrogen bonding increases packing density in the protein interior

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18315848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18315848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2105-9-S1-S17

1 reference

journals/bmcbi/MadhumalarSV08

25 July 2017

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

25 July 2017

1 reference

PubMed ID

18315848