Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex (Q24681633)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

8

Mikel Valle

0 references

Efstratios Mylonas

Efstratios Mylonas

3

0 references

Roberto Melero

Roberto Melero

2

0 references

Dmitri Svergun

Dmitri I Svergun

7

0 references

Alan Fersht

9

Alan R Fersht

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author name string

Henning Tidow

1

0 references

Stefan M V Freund

4

0 references

J Guenter Grossmann

5

0 references

José María Carazo

Proceedings of the National Academy of Sciences of the United States of America

6

0 references

language of work or name

English

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publication date

24 July 2007

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published in

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volume

104

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issue

30

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page(s)

12324-9

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

7 April 2017

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Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

7 April 2017

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

7 April 2017

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Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

7 April 2017

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Crystal structure of a beta-catenin/Tcf complex

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A folding transition and novel zinc finger accessory domain in the transcription factor ADR1

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

7 April 2017

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Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

7 April 2017

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Solution structure of the tetrameric minimum transforming domain of p53

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Surfing the p53 network

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Transcriptional coactivator complexes

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

7 April 2017

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p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

7 April 2017

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Identification of p53 as a sequence-specific DNA-binding protein

7 April 2017

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Definition of a consensus binding site for p53

7 April 2017

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

7 April 2017

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A global map of p53 transcription-factor binding sites in the human genome

7 April 2017

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Coupling of folding and binding for unstructured proteins

7 April 2017

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Coupling of local folding to site-specific binding of proteins to DNA

7 April 2017

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Structure-function-rescue: the diverse nature of common p53 cancer mutants

7 April 2017

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The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

28 September 2017

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p53--a natural cancer killer: structural insights and therapeutic concepts

28 September 2017

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Structure of the p53 core domain dimer bound to DNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

Solution structure of p53 core domain: structural basis for its instability

28 September 2017

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Core domain interactions in full-length p53 in solution

28 September 2017

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

28 September 2017

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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

The N-terminal domain of p53 is natively unfolded.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

p53 contains large unstructured regions in its native state

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

p300/CBP/p53 interaction and regulation of the p53 response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1941468

Small peptides activate the latent sequence-specific DNA binding function of p53.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Structural basis of DNA recognition by p53 tetramers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Cooperative binding of tetrameric p53 to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Latent and active p53 are identical in conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Interhelical angles in the solution structure of the oligomerization domain of p53: correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0705069104

NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17620598

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0705069104

1 reference

ADS bibcode

2007PNAS..10412324T

0 references

1 reference

1 reference

PubMed publication ID

17620598

1 reference