Apolipoprotein E: a major piece in the Alzheimer's disease puzzle. (Q33337322)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067484%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

review article

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title

Apolipoprotein E: a major piece in the Alzheimer's disease puzzle (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067484%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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1

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10 November 2019

author name string

R F Cowburn

series ordinal

2

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10 November 2019

publication date

1 July 2001

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Journal of Cellular and Molecular Medicine

10 November 2019

published in

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10 November 2019

volume

5

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10 November 2019

issue

3

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10 November 2019

page(s)

254-266

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A full genome scan for late onset Alzheimer's disease.

10 November 2019

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Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro

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Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures

21 January 2018

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Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization.

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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Apolipoprotein E genetic variation and Alzheimer's disease. a meta-analysis.

21 January 2018

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A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

21 January 2018

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A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

21 January 2018

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

21 January 2018

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

21 January 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.

21 January 2018

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

21 January 2018

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Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

21 January 2018

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A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

21 January 2018

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Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment.

21 January 2018

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Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

21 January 2018

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Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

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Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

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Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway

21 January 2018

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Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

21 January 2018

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Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.

21 January 2018

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Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

21 January 2018

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Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

21 January 2018

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Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide.

21 January 2018

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Beta-VLDL protects against A beta(1-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells

21 January 2018

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

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Cholesterol-dependent modulation of tau phosphorylation in cultured neurons

21 January 2018

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Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease

21 January 2018

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Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

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Differential neurotrophic effects of apolipoprotein E in aged transgenic mice

21 January 2018

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Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain.

21 January 2018

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Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

21 January 2018

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

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Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3β identified by nano-electrospray mass spectrometry

21 January 2018

1 reference

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

21 January 2018

1 reference

12 December 2020

A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

1 reference

12 December 2020

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

1 reference

12 December 2020

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1 reference

12 December 2020

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

1 reference

12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

1 reference

12 December 2020

Apolipoprotein E4: an allele associated with many diseases

1 reference

12 December 2020

No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice.

1 reference

12 December 2020

Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease

1 reference

12 December 2020

Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases.

1 reference

12 December 2020

Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts

1 reference

12 December 2020

Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione

1 reference

12 December 2020

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage

1 reference

12 December 2020

Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease.

1 reference

12 December 2020

A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele

1 reference

12 December 2020

Neurite degeneration elicited by apolipoprotein E peptides

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12 December 2020

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

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12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

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12 December 2020

The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific.

1 reference

12 December 2020

Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides

1 reference

12 December 2020

Human apolipoprotein E: the Alzheimer's disease connection.

1 reference

12 December 2020

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated

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12 December 2020

Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways

1 reference

12 December 2020

Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype

1 reference

12 December 2020

Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel.

1 reference

12 December 2020

10.1111/J.1582-4934.2001.TB00159.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067484%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067484%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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