Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation (Q33369693)

26 July 2017

Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation (English)

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26 July 2017

Michael D Rainey

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author name string

Maura E Charlton

series ordinal

2

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26 July 2017

Robert V Stanton

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3

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26 July 2017

Michael B Kastan

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4

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26 July 2017

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English

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publication date

1 September 2008

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26 July 2017

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26 July 2017

68

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26 July 2017

7466-7474

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26 July 2017

18

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describes a project that uses

26 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2559948/fullTextXML

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cites work

Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia

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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

21 June 2018

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Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.

21 June 2018

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DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

21 June 2018

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

21 June 2018

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Radiation and new molecular agents part I: targeting ATM-ATR checkpoints, DNA repair, and the proteasome

21 June 2018

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Src kinase regulation by phosphorylation and dephosphorylation

21 June 2018

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The development of imatinib as a therapeutic agent for chronic myeloid leukemia

21 June 2018

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 June 2018

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Cell-cycle checkpoints and cancer

21 June 2018

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Initiating cellular stress responses

21 June 2018

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 June 2018

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21 June 2018

A renaissance for SRC

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Cell cycle checkpoints and their impact on anticancer therapeutic strategies

21 June 2018

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21 June 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 June 2018

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

21 June 2018

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 June 2018

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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

21 June 2018

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ATM as a target for novel radiosensitizers

21 June 2018

1 reference

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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

21 June 2018

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 June 2018

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Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

21 June 2018

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The many substrates and functions of ATM

21 June 2018

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

21 June 2018

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Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiation

21 June 2018

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 June 2018

1 reference

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 June 2018

1 reference

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Substrate specificities and identification of putative substrates of ATM kinase family members

21 June 2018

1 reference

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The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

21 June 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

21 June 2018

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Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells

21 June 2018

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 June 2018

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PIKK-ing a new partner: a new role for PKB in the DNA damage response.

21 June 2018

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Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy.

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

The ATM-mediated DNA-damage response: taking shape.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559948

Ataxia-telangiectasia--broad implications for a rare disorder

31 October 2018

1 reference

12 December 2020

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function

1 reference

12 December 2020

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

1 reference

12 December 2020

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia

1 reference

12 December 2020

10.1158/0008-5472.CAN-08-0763

Identifiers

DOI

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26 July 2017

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26 July 2017

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