Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer (Q33572728)

28 July 2017

title

Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer (English)

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28 July 2017

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Marc Ladanyi

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28 July 2017

René Bernards

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Harold E. Varmus

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object named as

Harold Varmus

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Katerina Politi

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Mary Ann Melnick

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Scott Gettinger

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Anna Wurtz

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28 July 2017

Daniëlle A M Heideman

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object named as

Daniëlle A M Heideman

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28 July 2017

Elza C de Bruin

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28 July 2017

Catherine Cowell

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28 July 2017

Patricia H Warne

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28 July 2017

Ming Jiang

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28 July 2017

Rebecca E Saunders

5

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Zenta Walther

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28 July 2017

Guus J Heynen

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28 July 2017

Javier Gómez-Román

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28 July 2017

Almudena García-Castaño

13

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28 July 2017

Yixuan Gong

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Egbert F Smit

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Julian Downward

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28 July 2017

publication date

17 February 2014

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28 July 2017

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28 July 2017

volume

4

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28 July 2017

issue

5

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28 July 2017

page(s)

606-619

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Genome-scale CRISPR-Cas9 knockout screening in human cells

28 July 2017

cites work

1 reference

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21 June 2018

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Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers

21 June 2018

1 reference

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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

21 June 2018

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MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

21 June 2018

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21 June 2018

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Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

21 June 2018

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HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation

21 June 2018

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

21 June 2018

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

21 June 2018

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New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer

21 June 2018

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Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

21 June 2018

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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

21 June 2018

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21 June 2018

Global cancer statistics

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

21 June 2018

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

21 June 2018

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

21 June 2018

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KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies

21 June 2018

1 reference

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Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma

21 June 2018

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MEK1 mutations confer resistance to MEK and B-RAF inhibition

21 June 2018

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Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

21 June 2018

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PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

21 June 2018

1 reference

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Somatic mutations affect key pathways in lung adenocarcinoma

21 June 2018

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21 June 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 June 2018

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

21 June 2018

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

21 June 2018

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Epidermal growth factor receptor mutations in lung cancer

21 June 2018

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21 June 2018

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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

21 June 2018

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Selection of suitable reference genes for accurate normalization of gene expression profile studies in non-small cell lung cancer

21 June 2018

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

21 June 2018

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Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

21 June 2018

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

EGFR mutations in small-cell lung cancers in patients who have never smoked.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4011693

10.1158/2159-8290.CD-13-0741

31 October 2018

Identifiers

DOI

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28 July 2017

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28 July 2017

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