PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression (Q33577434)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19656489%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression (English)

1 reference

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4 February 2020

1 reference

1 reference

1

1 reference

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4 February 2020

François Pattou

7

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4 February 2020

Jorge Ferrer

9

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4 February 2020

author name string

Andreas Wiederkehr

2

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4 February 2020

Mathurin Baquié

3

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4 February 2020

Chunhua Dai

4

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4 February 2020

Alvin C Powers

5

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4 February 2020

Julie Kerr-Conte

6

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4 February 2020

Raymond J MacDonald

8

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4 February 2020

Claes B Wollheim

10

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4 February 2020

publication date

1 August 2009

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4 February 2020

1 reference

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4 February 2020

volume

10

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4 February 2020

issue

2

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page(s)

110-118

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Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation

4 February 2020

cites work

1 reference

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28 July 2018

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Channel regulation of glucose sensing in the pancreatic beta-cell

28 July 2018

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28 July 2018

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Metabolic cycling in control of glucose-stimulated insulin secretion

28 July 2018

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On the origin of the beta cell

28 July 2018

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Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells

28 July 2018

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Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell

28 July 2018

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Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis

28 July 2018

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Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene

28 July 2018

1 reference

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DNA replication and transcription in mammalian mitochondria

28 July 2018

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Minireview: implication of mitochondria in insulin secretion and action

28 July 2018

1 reference

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Molecular mechanisms of mitochondrial diabetes (MIDD).

28 July 2018

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The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets

28 July 2018

1 reference

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Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

28 July 2018

1 reference

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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

28 July 2018

1 reference

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Increased islet apoptosis in Pdx1+/- mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012862

Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements

28 July 2018

1 reference

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Mitochondrial function in normal and diabetic beta-cells

28 July 2018

1 reference

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Animal models for respiratory chain disease

28 July 2018

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Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

28 July 2018

1 reference

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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells

28 July 2018

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A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency

28 July 2018

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

28 July 2018

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Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.

28 July 2018

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31 October 2018

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Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease.

31 October 2018

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The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells

31 October 2018

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31 October 2018

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31 October 2018

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31 October 2018

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31 October 2018

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Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets

31 October 2018

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31 October 2018

1 reference

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Chromatin immunoprecipitation using isolated islets of Langerhans.

31 October 2018

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Experimental control of pancreatic development and maintenance

31 October 2018

1 reference

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Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012862

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012862

Cholesteryl ester transfer protein gene expression during differentiation of human preadipocytes to adipocytes in primary culture.

31 October 2018

1 reference

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Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19656489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Voltage-gated Ca(2+) influx and insulin secretion in human and mouse beta-cells are impaired by the mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP-37157

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19656489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2009.07.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19656489%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19656489%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

19656489

1 reference