Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (Q33597132)

28 July 2017

title

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (English)

1 reference

28 July 2017

0 references

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Kyle Leonard O'Hagan

4

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Hyewon Phee

Hyewon Phee

1

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Byron B Au-Yeung

Byron B Au-Yeung

2

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Jonathan Chernoff

Jonathan Chernoff

10

0 references

Arthur Weiss

11

Arthur Weiss

1 reference

28 July 2017

Olga Pryshchep

3

1 reference

28 July 2017

Stephanie Grace Fairbairn

5

1 reference

28 July 2017

Maria Radu

6

1 reference

28 July 2017

Rachelle Kosoff

7

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28 July 2017

Marianne Mollenauer

8

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28 July 2017

Debra Cheng

9

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28 July 2017

language of work or name

English

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publication date

13 May 2014

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28 July 2017

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28 July 2017

volume

3

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28 July 2017

page(s)

e02270

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ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling

28 July 2017

cites work

1 reference

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Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity

14 July 2018

1 reference

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Mouse models of PAK function

14 July 2018

1 reference

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Endogenous antigen tunes the responsiveness of naive B cells but not T cells

14 July 2018

1 reference

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F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

14 July 2018

1 reference

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

14 July 2018

1 reference

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Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation

14 July 2018

1 reference

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Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells

14 July 2018

1 reference

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Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

14 July 2018

1 reference

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Regulation of thymocyte positive selection and motility by GIT2.

14 July 2018

1 reference

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Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

14 July 2018

1 reference

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Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Rho family GTPases and their regulators in lymphocytes.

14 July 2018

1 reference

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KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors

14 July 2018

1 reference

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T cell dependence on mTOR signaling

14 July 2018

1 reference

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Rac GTPases play critical roles in early T-cell development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Thymic emigration: when and how T cells leave home

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Thymic emigration revisited

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Kruppel-like factor 2 regulates thymocyte and T-cell migration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Central tolerance: learning self-control in the thymus

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Vav-family proteins in T-cell signalling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Myosin-II-dependent localization and dynamics of F-actin during cytokinesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Upstream and downstream of mTOR

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

A novel role for p21-activated protein kinase 2 in T cell activation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Biology of the p21-activated kinases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Positive and negative selection of T cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Actin dynamics: assembly and disassembly of actin networks

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK)

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Involvement of p21ras distinguishes positive and negative selection in thymocytes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Identification of early stages of T lymphocyte development in the thymus cortex and medulla.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Inhibition of actin polymerization by latrunculin A.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

The majority of CD4+8- thymocytes are functionally immature

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Generation of T-cell function in organ culture of foetal mouse thymus. II. Mixed lymphocyte culture reactivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Selective requirement for MAP kinase activation in thymocyte differentiation.

14 July 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Phosphorylation of RhoGDI by p21-activated kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

The role of erk1 and erk2 in multiple stages of T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Constitutive activation of endocytosis by mutation of myoA, the myosin I gene of Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02270

Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017645

Recent thymic emigrants are distinct from most medullary thymocytes

30 October 2018

1 reference

12 December 2020

Raf regulates positive selection

1 reference

12 December 2020

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

1 reference

12 December 2020

Myosin phosphorylation by human cdc42-dependent S6/H4 kinase/gammaPAK from placenta and lymphoid cells

1 reference

12 December 2020

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

12 December 2020

The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells

1 reference

12 December 2020

Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.02270

1 reference

28 July 2017

1 reference

28 July 2017

1 reference