Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. (Q33597514)

28 July 2017

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. (English)

1 reference

28 July 2017

8

Michael Andreeff

1 reference

28 July 2017

Bing Z Carter

1

1 reference

28 July 2017

Duncan H Mak

2

1 reference

28 July 2017

Wendy D Schober

3

1 reference

28 July 2017

Erich Koller

4

1 reference

28 July 2017

Clemencia Pinilla

5

1 reference

28 July 2017

Lyubomir T Vassilev

6

1 reference

28 July 2017

John C Reed

7

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28 July 2017

language of work or name

English

0 references

publication date

6 November 2009

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28 July 2017

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28 July 2017

115

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28 July 2017

306-314

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28 July 2017

2

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describes a project that uses

28 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2808154/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.

14 July 2018

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Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

14 July 2018

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Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

14 July 2018

1 reference

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The dark side of a tumor suppressor: anti-apoptotic p53.

14 July 2018

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Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

14 July 2018

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Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity

14 July 2018

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Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

14 July 2018

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p53 and NF-kappaB crosstalk: IKKalpha tips the balance

14 July 2018

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Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells

14 July 2018

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Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

14 July 2018

1 reference

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Transfection of Smac sensitizes tumor cells to etoposide-induced apoptosis and eradicates established human hepatoma in vivo

14 July 2018

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Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells

14 July 2018

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

14 July 2018

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Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

14 July 2018

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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

14 July 2018

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Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

14 July 2018

1 reference

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

14 July 2018

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

14 July 2018

1 reference

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Differential effects of cell cycle regulatory protein p21(WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapy

14 July 2018

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

14 July 2018

1 reference

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

14 July 2018

1 reference

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Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

14 July 2018

1 reference

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Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.

14 July 2018

1 reference

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Murine stromal cell line HESS-5 maintains reconstituting ability of Ex vivo-generated hematopoietic stem cells from human bone marrow and cytokine-mobilized peripheral blood

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias

14 July 2018

1 reference

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Transcriptional cross talk between NF-kappaB and p53.

14 July 2018

1 reference

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IAP family proteins--suppressors of apoptosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

WAF1, a potential mediator of p53 tumor suppression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

14 July 2018

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

14 July 2018

1 reference

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Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Regulation of hemopoietic cell growth and development: experimental and clinical studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Regulation of hemopoiesis by bone marrow stromal cells and their products

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808154

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

30 October 2018

1 reference

12 December 2020

Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication

1 reference

12 December 2020

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

1 reference

12 December 2020

The human MDM-2 oncogene is overexpressed in leukemias

1 reference

12 December 2020

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

1 reference

12 December 2020

Analysis of the p53 and MDM-2 gene in acute myeloid leukemia

1 reference

12 December 2020

Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1 reference

12 December 2020

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1 reference

12 December 2020

Direct contact between CD34+lin- cells and stroma induces a soluble activity that specifically increases primitive hematopoietic cell production

1 reference

12 December 2020

Comparison of the sensitivity of normal and leukaemic myeloid progenitors to in-vitro incubation with cytotoxic drugs: a study of pharmacological purging

1 reference

12 December 2020

10.1182/BLOOD-2009-03-212563

Identifiers

DOI

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28 July 2017

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28 July 2017

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