The dark side of a tumor suppressor: anti-apoptotic p53. (Q37115437)

18 August 2017

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title

The dark side of a tumor suppressor: anti-apoptotic p53. (English)

1 reference

18 August 2017

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R U Jänicke

1

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PubMed ID

18356920

18 August 2017

D Sohn

series ordinal

2

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PubMed ID

18356920

18 August 2017

K Schulze-Osthoff

series ordinal

3

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18 August 2017

21 March 2008

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Cell Death & Differentiation

18 August 2017

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18 August 2017

15

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18 August 2017

6

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18 August 2017

959-976

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https://scigraph.springernature.com/pub.10.1038/cdd.2008.33

18 August 2017

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cites work

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Complicating the complexity of p53

21 January 2018

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How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

21 January 2018

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Death squads enlisted by the tumour suppressor p53.

21 January 2018

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Dissecting p53-dependent apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.33

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.33

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.33

Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.33

Outcomes of p53 activation--spoilt for choice

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.33

Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

A role for p53 in base excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Implication of p53 in base excision DNA repair: in vivo evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Transcriptional activation of the human glutathione peroxidase promoter by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

A novel p53-inducible gene coding for a microtubule-localized protein with G2-phase-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Netrin-1 and its receptors in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

DNA damage-induced cell death by apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53: traffic cop at the crossroads of DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Detection of a mouse OGG1 fragment during caspase-dependent apoptosis: oxidative DNA damage and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 regulation of DNA excision repair pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53-mediated protective responses to UV irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Regulation of the G2/M transition by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The multiple battles fought by anti-apoptotic p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The 14-3-3 cancer connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Unlocking the code of 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

14-3-3 proteins as potential oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Polo-like kinases and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Mice lacking a transcriptional corepressor Tob are predisposed to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Oxidant signals and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The functional interactions between the p53 and MAPK signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Redox control of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Human aldehyde dehydrogenase gene family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Mitochondrial superoxide dismutase: a promising target for new anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The molecular mechanism of protecting cells against oxidative stress by 2-selenium-bridged beta-cyclodextrin with glutathione peroxidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The thioredoxin system in retroviral infection and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The antioxidant function of the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The DNA excision repair system of the highly radioresistant bacterium Deinococcus radiodurans is facilitated by the pentose phosphate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 and metabolism: Inside the TIGAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 regulates mitochondrial respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Clues from worms: a Slug at Puma promotes the survival of blood progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

SLUG in cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Signals from within: the DNA-damage-induced NF-kappaB response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Integrating cell-signalling pathways with NF-kappaB and IKK function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

PIDD mediates NF-kappaB activation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

One, two, three--p53, p63, p73 and chemosensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Functional regulation of p73 and p63: development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

KLF4, p21 and context-dependent opposing forces in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Some p53-binding proteins that can function as arbiters of life and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The complexity of p53 stabilization and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

hGTSE-1 expression stimulates cytoplasmic localization of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: a comparative study to HGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-kappaB-dependent manner in Churg-Strauss syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Identification of expressed genes characterizing long-term survival in malignant glioma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Cyclooxygenase-2 as a target for anticancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Wild-type p53: tumors can't stand it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Mutant p53: an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Gain of function mutations in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Transcription regulation by mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

p53 downstream target genes and tumor suppression: a classical view in evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Tissue microarray analysis of hMSH2 expression predicts outcome in men with prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Dual specificity phosphatases: a gene family for control of MAP kinase function.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.33

7 January 2021

Identifiers

DOI

10.1038/CDD.2008.33

1 reference

18 August 2017

1 reference

PubMed ID

18356920