Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion (Q33636066)

28 July 2017

Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion (English)

1 reference

28 July 2017

Peng Li

1

1 reference

28 July 2017

Juan Du

2

1 reference

28 July 2017

John L Goodier

3

1 reference

28 July 2017

Jingwei Hou

4

1 reference

28 July 2017

Jian Kang

5

1 reference

28 July 2017

Haig H Kazazian

6

1 reference

28 July 2017

Ke Zhao

7

1 reference

28 July 2017

Xiao-Fang Yu

8

1 reference

28 July 2017

language of work or name

English

0 references

publication date

15 March 2017

1 reference

28 July 2017

Nucleic Acids Research

1 reference

28 July 2017

45

1 reference

28 July 2017

8

1 reference

28 July 2017

4619-4631

1 reference

Creative Commons Attribution 4.0 International

28 July 2017

start time

15 March 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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28 July 2018

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28 July 2018

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Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

28 July 2018

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The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

28 July 2018

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Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.

28 July 2018

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Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

28 July 2018

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Type I interferon controls propagation of long interspersed element-1.

28 July 2018

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The enemy within: endogenous retroelements and autoimmune disease

28 July 2018

1 reference

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Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Systemic involvement in TREX1-associated familial chilblain lupus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse

28 July 2018

1 reference

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RNase H2 roles in genome integrity revealed by unlinking its activities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Somatic expression of LINE-1 elements in human tissues.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Long interspersed nuclear elements (LINE-1): potential triggers of systemic autoimmune disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

One step at a time: endoplasmic reticulum-associated degradation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

The human LINE-1 retrotransposon creates DNA double-strand breaks.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Biology of mammalian L1 retrotransposons

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Determination of L1 retrotransposition kinetics in cultured cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

High frequency retrotransposition in cultured mammalian cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

A simple technique for quantitation of low levels of DNA damage in individual cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Reverse Transcriptase Encoded by a Human Transposable Element

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5416883

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

The exonuclease Trex1 restrains macrophage proinflammatory activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

A TREX1 mutation causing cerebral vasculopathy in a patient with familial chilblain lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

An improved plasmid DNA expression vector for direct injection into skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Full-length human L1 insertions retain the capacity for high frequency retrotransposition in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

The TREX1 C-terminal region controls cellular localization through ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Selective migration of neuralized embryonic stem cells to stem cell factor and media conditioned by glioma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

SAMHD1 prevents autoimmunity by maintaining genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

The MOV10 helicase inhibits LINE-1 mobility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKX178

Human l1 retrotransposition is associated with genetic instability in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28334850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKX178

1 reference

28 July 2017

1 reference

28 July 2017

1 reference