The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells (Q33636639)

28 July 2017

The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells (English)

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insulin secretion involved in cellular response to glucose stimulus

28 July 2017

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12

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28 July 2017

Maheul Ploton

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Olivier Briand

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Olivier Briand

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Rodolphe Carpentier

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Rodolphe Carpentier

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Nathalie Hennuyer

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Nathalie Hennuyer

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author name string

Audrey Helleboid-Chapman

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28 July 2017

François Pattou

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28 July 2017

Brigitte Vandewalle

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28 July 2017

Ericka Moerman

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28 July 2017

Valery Gmyr

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28 July 2017

Julie Kerr-Conte

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28 July 2017

Jérôme Eeckhoute

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28 July 2017

Philippe Lefebvre

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28 July 2017

language of work or name

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2 February 2012

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28 July 2017

Molecular Endocrinology

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28 July 2017

26

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3

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28 July 2017

399-413

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describes a project that uses

28 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5417130/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

21 June 2018

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FoxOs function synergistically to promote glucose production

21 June 2018

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21 June 2018

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The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity

21 June 2018

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Cholesterol in beta-cell dysfunction: the emerging connection between HDL cholesterol and type 2 diabetes.

21 June 2018

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Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

21 June 2018

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21 June 2018

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Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo.

21 June 2018

1 reference

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Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice

21 June 2018

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21 June 2018

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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

21 June 2018

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21 June 2018

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Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance

21 June 2018

1 reference

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Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity

21 June 2018

1 reference

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The NR4A family of orphan nuclear receptors are not required for adipogenesis

21 June 2018

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Roles and regulation of transcription factor MafA in islet beta-cells

21 June 2018

1 reference

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NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance

21 June 2018

1 reference

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets

21 June 2018

1 reference

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 June 2018

1 reference

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Targeting Nur77 translocation

21 June 2018

1 reference

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MAFA controls genes implicated in insulin biosynthesis and secretion

21 June 2018

1 reference

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Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

21 June 2018

1 reference

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FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

21 June 2018

1 reference

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Islet beta cell failure in type 2 diabetes

21 June 2018

1 reference

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21 June 2018

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Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.

21 June 2018

1 reference

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FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli

21 June 2018

1 reference

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Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells

21 June 2018

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Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts

21 June 2018

1 reference

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Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma

21 June 2018

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Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways

21 June 2018

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Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Weight gain as a risk factor for clinical diabetes mellitus in women

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417130

Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice

30 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22301783

12 December 2020

inferred from PubMed ID database lookup

Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22301783

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1210/ME.2011-1317

1 reference

release_e76qasi4zfgbpclfswog5pgmju

28 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e76qasi4zfgbpclfswog5pgmju

24 November 2022

mapped directly with Wikidata item

PMCID

5417130

1 reference

28 July 2017

1 reference