Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. (Q33677433)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008304%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss (English)

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15 January 2020

1

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15 January 2020

Kirk R Schultz

8

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15 January 2020

Francoise Pflumio

9

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15 January 2020

author name string

Xiuhua Gao

2

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15 January 2020

Florence Armstrong

3

1 reference

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15 January 2020

Samuel Gusscott

4

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15 January 2020

Qing Liu

5

1 reference

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15 January 2020

Amanda Larson Gedman

6

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15 January 2020

Larry H Matherly

7

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15 January 2020

Mingjian James You

10

1 reference

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15 January 2020

Andrew P Weng

11

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15 January 2020

language of work or name

English

0 references

publication date

11 December 2009

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15 January 2020

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15 January 2020

volume

115

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15 January 2020

issue

6

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15 January 2020

page(s)

1175-1184

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Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

15 January 2020

cites work

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

28 July 2018

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NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

28 July 2018

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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

28 July 2018

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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

28 July 2018

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28 July 2018

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In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

28 July 2018

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Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice

28 July 2018

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Notch signaling in leukemia

28 July 2018

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

28 July 2018

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

28 July 2018

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

28 July 2018

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Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia

28 July 2018

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Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation

28 July 2018

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Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1

28 July 2018

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

28 July 2018

1 reference

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

28 July 2018

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

28 July 2018

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Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

28 July 2018

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

28 July 2018

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

28 July 2018

1 reference

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Ligation-mediated PCR for genomic sequencing and footprinting

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

30 October 2018

1 reference

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Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826229

Plat-E: an efficient and stable system for transient packaging of retroviruses

30 October 2018

1 reference

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Homozygous MTS1 (p16INK4A) deletion in primary tumor cells of 163 leukemic patients

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20008304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20008304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20008304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2009-04-214718

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008304%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008304%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference