ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase (Q33717036)

28 July 2017

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase (English)

1 reference

28 July 2017

Agueda M Tejera

2

0 references

Francisca Mulero

Francisca Mulero

Óscar Fernández-Capetillo

5

0 references

Oscar Fernandez-Capetillo

6

0 references

Maria A Blasco

Maria A Blasco

7

0 references

Matilde Murga

4

Matilde Murga

1 reference

28 July 2017

Carolyn J McNees

1

1 reference

PubMed ID

20212315

28 July 2017

Paula Martínez

3

1 reference

PubMed ID

20212315

28 July 2017

language of work or name

English

0 references

publication date

1 March 2010

1 reference

28 July 2017

14

1 reference

inferred from page(s)

published in

Journal of Cell Biology

1 reference

28 July 2017

188

1 reference

28 July 2017

5

1 reference

28 July 2017

639-652

1 reference

Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Short telomeres initiate telomere recombination in primary and tumor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

How shelterin protects mammalian telomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Centromere mitotic recombination in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATM-like kinases and regulation of telomerase: lessons from yeast and mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

DNA damage response at functional and dysfunctional telomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

How telomeres are replicated

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

21 June 2018

Chromosome fragile sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomeres and human disease: ageing, cancer and beyond

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Effects of telomerase and telomere length on epidermal stem cell behavior

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Chromosomal instability at common fragile sites in Seckel syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

A DNA damage checkpoint response in telomere-initiated senescence

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

DNA damage foci at dysfunctional telomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATR Regulates Fragile Site Stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

A quantitative assay for telomere protection in Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATM function and telomere stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

DNA-PKcs is critical for telomere capping

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Cdc13 delivers separate complexes to the telomere for end protection and replication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomere length measurements using digital fluorescence microscopy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Normal telomere maintenance in immortal ataxia telangiectasia cell lines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

TLC1: template RNA component of Saccharomyces cerevisiae telomerase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Induction of sister chromatid exchanges at common fragile sites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Identification of yeast mutants with altered telomere structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Chromosome breakage and recombination at fragile sites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835929

Going against the grain: chemotaxis and infection in Vibrio cholerae

21 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

DNA methyltransferases control telomere length and telomere recombination in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

Semi-conservative DNA replication through telomeres requires Taz1

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200908136

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

21 January 2018

1 reference

12 December 2020

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres

1 reference

12 December 2020

Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1

1 reference

12 December 2020

Short telomeres on human chromosome 17p

1 reference

12 December 2020

Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200908136

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

PubMed ID

20212315