Instability, stabilization, and formulation of liquid protein pharmaceuticals (Q33719192)

28 July 2017

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title

Instability, stabilization, and formulation of liquid protein pharmaceuticals (English)

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28 July 2017

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Wang W

1

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PubMed ID

10460913

28 July 2017

language of work or name

English

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publication date

1 August 1999

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International Journal of Pharmaceutics

28 July 2017

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28 July 2017

185

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28 July 2017

2

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28 July 2017

129-188

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Monitoring of protein conformation by high-performance size-exclusion liquid chromatography and scanning diode array second-derivative UV absorption spectroscopy

28 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Enzymes and proteins from organisms that grow near and above 100 degrees C.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Biochemical diversity among sulfur-dependent, hyperthermophilic microorganisms

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein stability function relations: beta-lactoglobulin-A sulphydryl group reactivity and its relationship to protein unfolding stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein--solvent interactions in pharmaceutical formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Kinetic and thermodynamic thermal stabilities of ribonuclease A and ribonuclease B.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Remarkably slow folding of a small protein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of chemical glycosylation of RNase A on the protein stability and surface histidines accessibility in immobilized metal ion affinity electrophoresis (IMAGE) system

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Future directions in folding: the multi-state nature of protein structure

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein stability parameters measured by hydrogen exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Molten globule intermediate of recombinant human growth hormone: stabilization with surfactants

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of protein formulations: investigation of surfactant effects by a novel EPR spectroscopic technique

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Influence of glycerol on the structure and stability of ferric horse heart myoglobin: a SAXS and circular dichroism study.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Physical stabilization of insulin by glycosylation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Enhancement of the stability of thrombin by polyols: microcalorimetric studies

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Toward understanding insulin fibrillation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Chemical stability of insulin. 2. Formation of higher molecular weight transformation products during storage of pharmaceutical preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Chemical stability of insulin. 1. Hydrolytic degradation during storage of pharmaceutical preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Use of 2-hydroxypropyl-beta-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Fourth derivative spectra

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

NMR of modular proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A few amino acid substitutions are responsible for the higher thermostability of a novel NAD(+)-dependent bacillar alcohol dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Rational design of stable lyophilized protein formulations: some practical advice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Integration of mass spectrometry in analytical biotechnology

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Aggregation of rhDNase occurred during the compression of KBr pellets used for FTIR spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Polymer principles in protein structure and stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization of lyophilized porcine pancreatic elastase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein separation and purification in neat dimethyl sulfoxide.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Enzyme inactivation with shearing

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Shear Degradation of Fibrinogen in the Circulation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Techniques for assessing the effects of pharmaceutical excipients on the aggregation of porcine growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Domain structure and stability of human phenylalanine hydroxylase inferred from infrared spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Strategies to suppress aggregation of recombinant keratinocyte growth factor during liquid formulation development

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Conformational stability of muscle acylphosphatase: the role of temperature, denaturant concentration, and pH.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Maillard reaction and food processing. Application aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein folding and intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Determining the structures of large proteins and protein complexes by NMR.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The role of divalent cations in structure and function of murine adenosine deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Purification and characterization of an alpha-glucosidase from a hyperthermophilic archaebacterium, Pyrococcus furiosus, exhibiting a temperature optimum of 105 to 115 degrees C

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Solid-phase aggregation of proteins under pharmaceutically relevant conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Moisture-induced aggregation of lyophilized insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermophilic proteins: stability and function in aqueous and organic solvents

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The use of modulated temperature DSC for the study of pharmaceutical systems: potential uses and limitations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Kinetics of adsorption of proteins at interfaces: role of protein conformation in diffusional adsorption

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The denaturation and degradation of stable enzymes at high temperatures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Probing protein folding and stability using disulfide bonds

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Evidence for a common intermediate in insulin deamidation and covalent dimer formation: effects of pH and aniline trapping in dilute acidic solutions.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effects of temperature and SDS on the structure of beta-glycosidase from the thermophilic archaeon Sulfolobus solfataricus

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Interdomain interactions in the chimeric protein toxin sCD4(178)-PE40: a differential scanning calorimetry (DSC) study

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Aggregation and denaturation of apomyoglobin in aqueous urea solutions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Dominant forces in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermal stabilities of globular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Self-consistent field approach to protein structure and stability. I: pH dependence of electrostatic contribution

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Kinetic studies of protein folding using NMR spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Infrared methods for study of hemoglobin reactions and structures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein secondary structures in water from second-derivative amide I infrared spectra

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Spectroscopic study of secondary structure and thermal denaturation of recombinant human factor XIII in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Infrared and circular dichroism spectroscopic characterization of structural differences between beta-lactoglobulin A and B

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization centers in proteins: identification, characterization and predictions.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Improved folding yields of a model protein using protein disulfide isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Equilibrium NMR studies of unfolded and partially folded proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The use of fluorescence methods to monitor unfolding transitions in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effects of temperature and concentration on bovine lens alpha-crystallin secondary structure: a circular dichroism spectroscopic study.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Destabilization of human serum albumin by polyethylene glycols studied by thermodynamical equilibrium and kinetic approaches

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Recombinant factor VIII SQ--inactivation kinetics in aqueous solution and the influence of disaccharides and sugar alcohols

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

High sensitivity analysis of proteins and peptides by capillary electrophoresis-tandem mass spectrometry: recent developments in technology and applications.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Identification of a beta-lactoglobulin lactosylation site.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of osmolytes on the exchange rates of backbone amide protons in proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Oxidation of human insulin-like growth factor I in formulation studies: kinetics of methionine oxidation in aqueous solution and in solid state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Oxidation of human insulin-like growth factor I in formulation studies, II. Effects of oxygen, visible light, and phosphate on methionine oxidation in aqueous solution and evaluation of possible mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermal stability of human immunoglobulins with sorbitol. A critical evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

DSC studies on bovine serum albumin denaturation. Effects of ionic strength and SDS concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Enzyme stabilization: state of the art.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Chemical degradation kinetics of recombinant hirudin (HV1) in aqueous solution: effect of pH

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermodynamic stability and folding of GroEL minichaperones

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Determination of soluble and membrane protein structure by Fourier transform infrared spectroscopy. II. Experimental aspects, side chain structure, and H/D exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Conformational states of beta-lactamase: molten-globule states at acidic and alkaline pH with high salt

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Acid-induced folding of heme proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Lyophilization-induced reversible changes in the secondary structure of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of interleukin 1 beta (IL-1 beta) in aqueous solution: analytical methods, kinetics, products, and solution formulation implications

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

PEGylation prevents the N-terminal degradation of megakaryocyte growth and development factor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Fractal analysis of aggregates formed by heating dilute BSA solutions using light scattering methods

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Investigation of secondary and tertiary structural changes of cytochrome c in complexes with anionic lipids using amide hydrogen exchange measurements: an FTIR study.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The role of molecular chaperones in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Surface denaturation at solid-void interface--a possible pathway by which opalescent particulates form during the storage of lyophilized tissue-type plasminogen activator at high temperatures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Solution conformation of N-terminal fragments of trichosanthin small domain (TCS 182-200). Circular dichroic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A novel group of abyssal methanogenic archaebacteria (Methanopyrus) growing at 110 °C

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Biphasic denaturation of human placental alkaline phosphatase in guanidinium chloride

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of recombinant consensus interferon to air-jet and ultrasonic nebulization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein structure and function at low temperatures.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein stability and molecular adaptation to extreme conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability studies on pig heart mitochondrial malate dehydrogenase: the effect of salts and amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermodynamic analysis of the stabilisation of pig heart mitochondrial malate dehydrogenase and maize leaf phosphoenolpyruvate carboxylase by different salts, amino acids and polyols

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Microdialysis sampling to determine the pharmacokinetics of unbound SDZ ICM 567 in blood and brain in awake, freely-moving rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermodynamics of denaturation of mutants of barnase with disulfide crosslinks

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of radical scavengers on the inactivation of papain by ascorbic acid in the presence of cupric ions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Use of poloxamer polymers to stabilize recombinant human growth hormone against various processing stresses

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of surfactants on the physical stability of recombinant human growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Aggregation of recombinant human interferon gamma: kinetics and structural transitions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Acute and long-term stability studies of deoxy hemoglobin and characterization of ascorbate-induced modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Chemical pathways of peptide degradation: IX. Metal-catalyzed oxidation of histidine in model peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Contribution of the surface free energy perturbation to protein-solvent interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermal unfolding of small proteins with SH3 domain folding pattern.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of nonaqueous suspension formulations of plasma derived factor IX and recombinant human alpha interferon at elevated temperatures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Salt effects on protein stability: two-stranded alpha-helical coiled-coils containing inter- or intrahelical ion pairs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Species differences of serum albumins: II. Chemical and thermal stability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

An exceptionally stable helix from the ribosomal protein L9: implications for protein folding and stability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Domain structure, stability and domain-domain interactions in recombinant factor XIII.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The kinetic studies on the intramolecular SH, S-S exchange reaction of bovine mercaptalbumin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of glycosylation on the stability of alpha1-antitrypsin toward urea denaturation and thermal deactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A method for assessing the stability of a membrane protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Chemical pathways of peptide degradation. V. Ascorbic acid promotes rather than inhibits the oxidation of methionine to methionine sulfoxide in small model peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Aggregation and precipitation of human relaxin induced by metal-catalyzed oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Inhibitory effect of sugars and polyols on the metal-catalyzed oxidation of human relaxin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effects of reducing sugars on the chemical stability of human relaxin in the lyophilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

On the role of surface tension in the stabilization of globular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein glycosylation. Structural and functional aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Glycoprotein pharmaceuticals: scientific and regulatory considerations, and the US Orphan Drug Act

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

In vitro methionine oxidation of recombinant human leptin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The peptide backbone plays a dominant role in protein stabilization by naturally occurring osmolytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The observed change in heat capacity accompanying the thermal unfolding of proteins depends on the composition of the solution and on the method employed to change the temperature of unfolding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Metal ion stabilization of the conformation of a recombinant 19‐kDa catalytic fragment of human fibroblast collagenase

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Dynamic Structure/Function Relationships in the alpha-Chymotrypsin Deactivation Process by Heat and pH

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein denaturation by combined effect of shear and air-liquid interface

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Design, synthesis, and testing of insulin hexamer-stabilizing agents

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Approaches for increasing the solution stability of proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of protein pharmaceuticals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Accumulation of Mannosylglycerate and Di-myo-Inositol-Phosphate by Pyrococcus furiosus in Response to Salinity and Temperature.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Substantial increase of protein stability by multiple disulphide bonds

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization of a protein by guanidinium chloride

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The application of capillary electrophoresis for monitoring effects of excipients on protein conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermal unfolding of proteins at high pH range studied by UV absorbance

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Oxidation of recombinant human parathyroid hormone: effect of oxidized position on the biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein mass spectrometry: applications to analytical biotechnology

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The kinetics of relaxin oxidation by hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Preparation of excipient-free recombinant human tissue-type plasminogen activator by lyophilization from ammonium bicarbonate solution: an investigation of the two-stage sublimation phenomenon

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Measuring and increasing protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Forces contributing to the conformational stability of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein structural segments and their interconnections derived from optical spectra. Thermal unfolding of ribonuclease T1 as an example.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Simulations of reversible protein aggregate and crystal structure

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The hyperthermophilic glycolytic enzyme enolase in the archaeon, Pyrococcus furiosus: comparison with mesophilic enolases.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Insights into thermal resistance of proteins from the intrinsic stability of their alpha-helices

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The effects of formulation variables on the stability of freeze-dried human growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The stability of insulin in crystalline and amorphous solids: observation of greater stability for the amorphous form

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Pressure denaturation of proteins: evaluation of compressibility effects

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Optimization of lyophilization conditions for recombinant human interleukin-2 by dried-state conformational analysis using Fourier-transform infrared spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Non-native local interactions in protein folding and stability: introducing a helical tendency in the all beta-sheet alpha-spectrin SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Analysis of protein conformational characteristics related to thermostability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Flexibility plot of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Characterization of Di-myo-Inositol-1,1(prm1)-Phosphate in the Hyperthermophilic Bacterium Thermotoga maritima.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of the chaperone-like alpha-crystallin on the refolding of lysozyme and ribonuclease A

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization of Enzymes against Thermal Stress and Freeze-Drying by Mannosylglycerate

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Hydrogen exchange studies of protein structure

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein stability: still an unsolved problem

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A model for the denaturation and aggregation of beta-lactoglobulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Characterisation of the glass transition of an amorphous drug using modulated DSC

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Assisted protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Deamidation at asparagine-88 in recombinant human interleukin 2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Degradation pathways for recombinant human macrophage colony-stimulating factor in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Kinetic and thermodynamic studies of the folding/unfolding of a tryptophan-containing mutant of ribonuclease A

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Aqueous stability of recombinant human thrombopoietin as a function of processing schemes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Major degradation products of basic fibroblast growth factor: detection of succinimide and iso-aspartate in place of aspartate

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Approaches to analysis of aggregates and demonstrating mass balance in pharmaceutical protein (basic fibroblast growth factor) formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A relationship between protein stability and protein function

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The denatured state (the other half of the folding equation) and its role in protein stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effects of salt bridges on protein structure and design.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Mechanism of insulin aggregation and stabilization in agitated aqueous solutions.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stabilization of human epidermal growth factor (hEGF) in aqueous formulation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Specific aggregation of partially folded polypeptide chains: the molecular basis of inclusion body composition.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Unfolding of apomyoglobin from Aplysia limacina : the effect of salt and ph on the cooperativity of folding 1 1Edited by P. E. Wright

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of secondary structure on the rate of deamidation of several growth hormone releasing factor analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Solid-state stability of human insulin. I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Determination of protein secondary structure by Fourier transform infrared spectroscopy: a critical assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Resolution-enhanced Fourier transform infrared spectroscopy of enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Native protein fluctuations: the conformational-motion temperature and the inverse correlation of protein flexibility with protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Halothane, an inhalational anesthetic agent, increases folding stability of serum albumin.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Lysine vasopressin undergoes rapid glycation in the presence of reducing sugars

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Water as ligand: preferential binding and exclusion of denaturants in protein unfolding

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of ribonuclease A in solution and the freeze-dried state

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Formulation design of acidic fibroblast growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

I. Study of protein aggregation due to heat denaturation: A structural approach using circular dichroism spectroscopy, nuclear magnetic resonance, and static light scattering.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

II. Electrostatic effect in the aggregation of heat-denatured RNase A and implications for protein additive design.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

High-pressure effects on vacuolar H+-ATPase from etiolated mung bean seedlings

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Enzymes in low water systems

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Irreversible inactivation of interleukin 2 in a pump-based delivery environment

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Structural changes of IgG induced by heat treatment and by adsorption onto a hydrophobic Teflon surface studied by circular dichroism spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein thermal stability: hydrogen bonds or internal packing?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Protein thermal stability, hydrogen bonds, and ion pairs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Physical stabilization of acidic fibroblast growth factor by polyanions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Thermal stability of low molecular weight urokinase during heat treatment. II. Effect of polymeric additives

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effects of a Naturally Occurring Compatible Osmolyte on the Internal Dynamics of Ribonuclease A

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Influence of the carbohydrate moiety on the stability of glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Oral protein drug delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Size-exclusion chromatography with on-line light-scattering, absorbance, and refractive index detectors for studying proteins and their interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Perturbations of the denatured state ensemble: modeling their effects on protein stability and folding kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Mechanism of the stabilization of ribonuclease A by sorbitol: preferential hydration is greater for the denatured then for the native protein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

The thermodynamic mechanism of protein stabilization by trehalose

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Solution structure of recombinant human interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Secondary structure and protein deamidation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

On the pH dependence of protein stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Secondary structure characterization of microparticulate insulin powders

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Stability of beta-galactosidase, a model protein drug, is related to water mobility as measured by 17O nuclear magnetic resonance (NMR).

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Is stability prediction possible for protein drugs? Denaturation kinetics of beta-galactosidase in solution.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Application of accelerated testing to shelf-life prediction of commercial protein preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Softening temperature of lyophilized bovine serum albumin and gamma-globulin as measured by spin-spin relaxation time of protein protons

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effect of high molecular mobility of poly(vinyl alcohol) on protein stability of lyophilized gamma-globulin formulations

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

NMR Study of the Cold, Heat, and Pressure Unfolding of Ribonuclease A

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Metal-catalyzed oxidation of histidine in human growth hormone. Mechanism, isotope effects, and inhibition by a mild denaturing alcohol

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

Effects of polyaminocarboxylate metal chelators on iron-thiolate induced oxidation of methionine- and histidine-containing peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5173%2899%2900152-0

7 January 2021

10.1016/S0378-5173(99)00152-0

Identifiers

DOI

1 reference

28 July 2017

1 reference

PubMed ID

10460913