The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition. (Q33748087)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20053987%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition (English)

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16 January 2020

0 references

1 reference

1 reference

3

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16 January 2020

4

Ronit Sharon

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16 January 2020

author name string

Virginie Loeb

series ordinal

1

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16 January 2020

Eugenia Yakunin

series ordinal

2

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16 January 2020

language of work or name

English

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publication date

6 January 2010

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Journal of Biological Chemistry

16 January 2020

published in

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16 January 2020

volume

285

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16 January 2020

issue

10

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16 January 2020

page(s)

7334-7343

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What causes cell death in Parkinson's disease?

16 January 2020

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Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model

21 June 2018

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p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

21 June 2018

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21 June 2018

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21 June 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 June 2018

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 June 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 June 2018

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

21 June 2018

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 June 2018

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Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

21 June 2018

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21 June 2018

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

21 June 2018

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

21 June 2018

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Evaluation of enzymatic assays and compounds affecting ATP production in mitochondrial respiratory chain complex I deficiency

21 June 2018

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 June 2018

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 June 2018

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

21 June 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 June 2018

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A role for alpha-synuclein in the regulation of dopamine biosynthesis

21 June 2018

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Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

21 June 2018

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alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

21 June 2018

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Alpha-synuclein and neurodegenerative diseases

21 June 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 June 2018

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 June 2018

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Neuropathology of synuclein aggregates

21 June 2018

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Alpha-synuclein in Lewy bodies

21 June 2018

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An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes

21 June 2018

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

21 June 2018

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Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion

21 June 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 June 2018

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 June 2018

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Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

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Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

1 reference

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Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

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The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

21 January 2018

1 reference

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Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.

21 January 2018

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α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

21 January 2018

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Blue-native gels to isolate protein complexes from mitochondria.

30 October 2018

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Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

30 October 2018

1 reference

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Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

21 January 2018

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12 December 2020

Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

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12 December 2020

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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12 December 2020

Identifiers

DOI

10.1074/JBC.M109.061051

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20053987%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20053987%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

20053987

1 reference