p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition (Q28579903)

5

object named as

C. Warren Olanow

1 reference

31 January 2017

Venugopalan D. Nair

1

1 reference

31 January 2017

Kevin St P. McNaught

2

1 reference

31 January 2017

Javier González-Maeso

3

1 reference

31 January 2017

Stuart C. Sealfon

Journal of Biological Chemistry

4

1 reference

31 January 2017

language of work or name

English

0 references

publication date

22 December 2006

1 reference

31 January 2017

1 reference

31 January 2017

281

1 reference

31 January 2017

51

1 reference

31 January 2017

39550–39560

1 reference

31 January 2017

Molecular pathophysiology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Failure of the ubiquitin-proteasome system in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Brain proteasomal function in sporadic Parkinson's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Transcriptional regulation by p53: one protein, many possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

The complexity of p53 stabilization and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Dissecting p53-dependent apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Regulating the p53 system through ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Proteasome inhibition and Parkinson's disease modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Lack of nigrostriatal pathology in a rat model of proteasome inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603950200