Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. (Q33756997)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24796395%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma (English)

1 reference

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17 March 2020

0 references

9

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17 March 2020

Nicholas K Foreman

12

1 reference

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17 March 2020

author name string

Sujatha Venkataraman

1

1 reference

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17 March 2020

Irina Alimova

2

1 reference

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17 March 2020

Ilango Balakrishnan

3

1 reference

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17 March 2020

Peter Harris

4

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17 March 2020

Diane K Birks

5

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17 March 2020

Andrea Griesinger

6

1 reference

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17 March 2020

Vladimir Amani

7

1 reference

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17 March 2020

Brian Cristiano

8

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17 March 2020

Michael D Taylor

10

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17 March 2020

Michael Handler

11

1 reference

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17 March 2020

Rajeev Vibhakar

13

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17 March 2020

language of work or name

English

0 references

publication date

1 May 2014

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17 March 2020

1 reference

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17 March 2020

volume

5

1 reference

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17 March 2020

issue

9

1 reference

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17 March 2020

page(s)

2355-2371

1 reference

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BET bromodomain inhibition of MYC-amplified medulloblastoma.

17 March 2020

cites work

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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.

21 June 2018

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A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity

21 June 2018

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Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

21 June 2018

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

21 June 2018

1 reference

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MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma

21 June 2018

1 reference

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 June 2018

1 reference

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Signals that regulate the oncogenic fate of neural stem cells and progenitors

21 June 2018

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Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

21 June 2018

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Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells

21 June 2018

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In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76

21 June 2018

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BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

21 June 2018

1 reference

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

21 June 2018

1 reference

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BET domain co-regulators in obesity, inflammation and cancer

21 June 2018

1 reference

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The clinical implications of medulloblastoma subgroups

21 June 2018

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Small molecule bromodomain inhibitors: extending the druggable genome

21 June 2018

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Histone recognition and large-scale structural analysis of the human bromodomain family

21 June 2018

1 reference

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Medulloblastoma stem cells: where development and cancer cross pathways.

21 June 2018

1 reference

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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

21 June 2018

1 reference

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Myc proteins in brain tumor development and maintenance

21 June 2018

1 reference

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An animal model of MYC-driven medulloblastoma

21 June 2018

1 reference

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MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma

21 June 2018

1 reference

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 June 2018

1 reference

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 June 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 June 2018

1 reference

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Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 June 2018

1 reference

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

21 June 2018

1 reference

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Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc.

21 June 2018

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A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs

21 June 2018

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Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables

21 June 2018

1 reference

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Selective inhibition of BET bromodomains

21 June 2018

1 reference

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Medulloblastoma comprises four distinct molecular variants

21 June 2018

1 reference

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Pleiotropic role for MYCN in medulloblastoma.

21 June 2018

1 reference

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Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.

21 June 2018

1 reference

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

21 June 2018

1 reference

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058011

HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.

21 June 2018

1 reference

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

21 June 2018

1 reference

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Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma

21 June 2018

1 reference

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The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058011

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

21 June 2018

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 June 2018

1 reference

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Identification of human brain tumour initiating cells

21 June 2018

1 reference

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Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058011

Prediction of central nervous system embryonal tumour outcome based on gene expression

21 June 2018

1 reference

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The developmental biology of brain tumors.

21 June 2018

1 reference

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Reversible tumorigenesis by MYC in hematopoietic lineages

21 June 2018

1 reference

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Sox2 requirement in sonic hedgehog-associated medulloblastoma

21 June 2018

1 reference

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BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058011

Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058011

30 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24796395

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.1659

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24796395%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24796395%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24796395%20AND%20SRC:MED&resulttype=core&format=json