Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. (Q33791305)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function (English)

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2 April 2020

1

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2 April 2020

Kouhei Shimizu

3

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2 April 2020

Brian J North

4

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2 April 2020

Daming Gao

6

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2 April 2020

Hiroyuki Inuzuka

7

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2 April 2020

Wenyi Wei

8

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2 April 2020

author name string

Kohei Ogura

2

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2 April 2020

Jinfang Zhang

5

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2 April 2020

publication date

14 February 2017

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2 April 2020

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2 April 2020

volume

10

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2 April 2020

issue

466

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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

2 April 2020

cites work

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4 July 2018

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Autoactivation of the MDM2 E3 ligase by intramolecular interaction

4 July 2018

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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

4 July 2018

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The Regulation of Multiple p53 Stress Responses is Mediated through MDM2

4 July 2018

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4 July 2018

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4 July 2018

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Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

4 July 2018

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Two-phase dynamics of p53 in the DNA damage response.

4 July 2018

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Acetyltransferase p300 regulates NBS1-mediated DNA damage response

4 July 2018

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Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

4 July 2018

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Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

4 July 2018

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The p53 orchestra: Mdm2 and Mdmx set the tone

4 July 2018

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ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage

4 July 2018

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

4 July 2018

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Acetylation of non-histone proteins modulates cellular signalling at multiple levels

4 July 2018

1 reference

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A complex barcode underlies the heterogeneous response of p53 to stress

4 July 2018

1 reference

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Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

4 July 2018

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

4 July 2018

1 reference

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

4 July 2018

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Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

4 July 2018

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p53 ubiquitination: Mdm2 and beyond

4 July 2018

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Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793

Acetylation and deacetylation of non-histone proteins

4 July 2018

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

4 July 2018

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A new effector pathway links ATM kinase with the DNA damage response

4 July 2018

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

4 July 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

4 July 2018

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

4 July 2018

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Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-alpha

4 July 2018

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

4 July 2018

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PUMA, a novel proapoptotic gene, is induced by p53

4 July 2018

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Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

Surfing the p53 network

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

4 July 2018

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Identification of a cryptic nucleolar-localization signal in MDM2

4 July 2018

1 reference

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

4 July 2018

1 reference

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DNA damage activates p53 through a phosphorylation-acetylation cascade

4 July 2018

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The MDM2 gene amplification database

4 July 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

4 July 2018

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4 July 2018

Nuclear protein import

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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

4 July 2018

1 reference

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Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

30 October 2018

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The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

30 October 2018

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10.1126/SCISIGNAL.AAI8026

30 October 2018

Identifiers

DOI

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2 April 2020

1 reference

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2 April 2020

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