Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A (Q33826976)

29 July 2017

title

Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A (English)

1 reference

29 July 2017

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1

Abhinav Grover

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29 July 2017

7

Durai Sundar

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29 July 2017

2

Ashutosh Shandilya

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29 July 2017

6

Virendra S Bisaria

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29 July 2017

3

Vibhuti Agrawal

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29 July 2017

Piyush Pratik

4

1 reference

29 July 2017

Divya Bhasme

series ordinal

5

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29 July 2017

publication date

15 February 2011

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29 July 2017

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29 July 2017

volume

12 Suppl 1

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29 July 2017

page(s)

S30

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Withaferin A targets heat shock protein 90 in pancreatic cancer cells

29 July 2017

cites work

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The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy

4 July 2018

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Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

4 July 2018

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The Hsp90 molecular chaperone: an open and shut case for treatment

4 July 2018

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A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

4 July 2018

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4 July 2018

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Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells

4 July 2018

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Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

4 July 2018

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4 July 2018

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4 July 2018

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Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

4 July 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

4 July 2018

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A proteomic snapshot of the human heat shock protein 90 interactome

4 July 2018

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HSP90 and the chaperoning of cancer

4 July 2018

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Search for natural products related to regeneration of the neuronal network.

4 July 2018

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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

4 July 2018

1 reference

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Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

4 July 2018

1 reference

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Pathways of chaperone-mediated protein folding in the cytosol

4 July 2018

1 reference

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Therapeutic and diagnostic implications of Hsp90 activation

4 July 2018

1 reference

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Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

4 July 2018

1 reference

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

4 July 2018

1 reference

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Cdc37 goes beyond Hsp90 and kinases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification

4 July 2018

1 reference

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Heat shock protein 90 as a molecular target for cancer therapeutics

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

4 July 2018

1 reference

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Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation

4 July 2018

1 reference

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Efficient docking of peptides to proteins without prior knowledge of the binding site

4 July 2018

1 reference

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Hsp90: chaperoning signal transduction

4 July 2018

1 reference

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Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

4 July 2018

1 reference

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Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review

4 July 2018

1 reference

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The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

4 July 2018

1 reference

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Modelling of factor Xa-inhibitor complexes: a computational flexible docking approach

4 July 2018

1 reference

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p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

4 July 2018

1 reference

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

4 July 2018

1 reference

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Automated docking of flexible ligands: applications of AutoDock

4 July 2018

1 reference

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Molecular chaperones in cellular protein folding

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Differential expression of heat shock proteins in pancreatic carcinoma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Withasteroids, a growing group of naturally occurring steroidal lactones

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Unusual expression and localization of heat-shock proteins in human tumor cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

ParDOCK: an all atom energy based Monte Carlo docking protocol for protein-ligand complexes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Molecular docking of competitive phosphodiesterase inhibitors

29 October 2018

1 reference

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Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044286

Anti-granuloma activity of Iraqi Withania somnifera

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21342561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21342561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21342561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2105-12-S1-S30

1 reference

journals/bmcbi/GroverSAPBBS11

29 July 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

0 references

1 reference

29 July 2017

1 reference