What transgenic mice tell us about neurodegenerative disease (Q33843472)

29 July 2017

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title

What transgenic mice tell us about neurodegenerative disease (English)

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29 July 2017

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Gurney ME

1

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29 July 2017

language of work or name

English

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publication date

1 March 2000

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29 July 2017

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29 July 2017

volume

22

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29 July 2017

issue

3

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29 July 2017

page(s)

297-304

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

29 July 2017

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

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Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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Epidemiologic investigations of amyotrophic lateral sclerosis. 2. Familial aggregations indicative of dominant inheritance. II.

21 January 2018

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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

21 January 2018

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

21 January 2018

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

21 January 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

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Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

21 January 2018

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The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies

21 January 2018

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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

21 January 2018

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

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Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

21 January 2018

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The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

21 January 2018

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Carboxyfullerenes as neuroprotective agents.

21 January 2018

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Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

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Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

21 January 2018

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A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

21 January 2018

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Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis

21 January 2018

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The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

21 January 2018

1 reference

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

21 January 2018

1 reference

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

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Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

21 January 2018

1 reference

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Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

21 January 2018

1 reference

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Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

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Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Trinucleotide repeat length instability and age of onset in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

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Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Identification of a self-association region within the SCA1 gene product, ataxin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

Inhibition of ICE slows ALS in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F%28SICI%291521-1878%28200003%2922%3A3%3C297%3A%3AAID-BIES12%3E3.0.CO%3B2-I

10.1002/(SICI)1521-1878(200003)22:3<297::AID-BIES12>3.0.CO;2-I

21 January 2018

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DOI

1 reference

29 July 2017

1 reference