Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. (Q48491870)

12 February 2018

title

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. (English)

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12 February 2018

author name string

Qian S

1

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12 February 2018

Jiang P

2

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12 February 2018

Guan XM

3

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12 February 2018

Singh G

4

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12 February 2018

Trumbauer ME

5

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12 February 2018

Yu H

6

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12 February 2018

Chen HY

7

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12 February 2018

Van de Ploeg LH

8

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12 February 2018

Zheng H

9

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12 February 2018

language of work or name

English

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publication date

1 March 1998

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12 February 2018

published in

Neuron

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12 February 2018

volume

20

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12 February 2018

issue

3

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12 February 2018

page(s)

611-617

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12 February 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

The presenilin genes: a new gene family involved in Alzheimer disease pathology

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Regulation of Thy-1 gene expression in transgenic mice

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

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7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Alzheimer's disease: genotypes, phenotypes, and treatments

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Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

Chromosomal localization of the human Thy-1 gene

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

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Identifiers

DOI

1 reference

12 February 2018

PubMed ID

9539133

1 reference

12 February 2018