Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation (Q33867427)

29 July 2017

Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation (English)

1 reference

29 July 2017

1 reference

Heidi L Kenerson

1

1 reference

29 July 2017

Matthew M Yeh

series ordinal

2

1 reference

29 July 2017

Raymond S Yeung

series ordinal

3

1 reference

29 July 2017

language of work or name

English

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publication date

29 March 2011

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29 July 2017

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29 July 2017

6

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29 July 2017

3

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29 July 2017

e18075

1 reference

Creative Commons Attribution 4.0 International

29 July 2017

start time

29 March 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

28 July 2018

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mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

28 July 2018

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

28 July 2018

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28 July 2018

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An emerging role of mTOR in lipid biosynthesis.

28 July 2018

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Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats

28 July 2018

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Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

28 July 2018

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FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes

28 July 2018

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28 July 2018

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Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

28 July 2018

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Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

28 July 2018

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28 July 2018

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Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

28 July 2018

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The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy

28 July 2018

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Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism

28 July 2018

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Mechanisms of Disease: hepatic steatosis in type 2 diabetes--pathogenesis and clinical relevance

28 July 2018

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Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

28 July 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

28 July 2018

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The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma

28 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

28 July 2018

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

28 July 2018

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Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease

28 July 2018

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Growing roles for the mTOR pathway

28 July 2018

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Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

28 July 2018

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

28 July 2018

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

28 July 2018

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Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

28 July 2018

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Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

28 July 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

28 July 2018

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Inhibition of protein kinase B/Akt. implications for cancer therapy

28 July 2018

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

28 July 2018

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

28 July 2018

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Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

28 July 2018

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28 July 2018

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

28 July 2018

1 reference

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

28 July 2018

1 reference

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The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.

21 January 2018

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Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver

21 January 2018

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Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

21 January 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

21 January 2018

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Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018075

The role of FOXO in the regulation of metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018075

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

21 January 2018

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Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts

21 January 2018

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A phosphorylation cascade controls the degradation of active SREBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018075

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018075

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21479224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21479224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0018075

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference