Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib (Q33878944)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

6

Jeffrey M Trent

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Megan L Goodall

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Tong Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Katie R Martin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Matthew G Kortus

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Audra L Kauffman

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Stephen Gately

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

publication date

1 June 2014

1 reference

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19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

1120-1136

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

19 March 2020

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The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Computational model for autophagic vesicle dynamics in single cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Guidelines for the use and interpretation of assays for monitoring autophagy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Deconvoluting the context-dependent role for autophagy in cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

From genes to drugs: targeted strategies for melanoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

The autophagic paradox in cancer therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy as a target for anticancer therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Pancreatic cancers require autophagy for tumor growth

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

How can we identify parasite genes that underlie antimalarial drug resistance?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Akt and autophagy cooperate to promote survival of drug-resistant glioma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagic pathways as new targets for cancer drug development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Design and synthesis of chloroquine analogs with anti-breast cancer property

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy: cerebral home cooking

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

The role of autophagy in tumour development and cancer therapy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy regulates lipid metabolism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy fights disease through cellular self-digestion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Role of autophagy in cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy: from phenomenology to molecular understanding in less than a decade

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Combination of tunicamycin with anticancer drugs synergistically enhances their toxicity in multidrug-resistant human ovarian cystadenocarcinoma cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

The role of autophagy in cancer development and response to therapy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Inhibition of macroautophagy triggers apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Mutations of the BRAF gene in human cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

28 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Eaten alive: a history of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Anti- and pro-tumor functions of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Drug combination studies and their synergy quantification using the Chou-Talalay method

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28594

Novel drug targets in malaria parasite with potential to yield antimalarial drugs with long useful therapeutic lives.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091172

ACTIVITY OF A NEW ANTIMALARIAL AGENT, CHLOROQUINE (SN 7618)

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24879157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/AUTO.28594

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879157%20AND%20SRC:MED&resulttype=core&format=json