Regulation and function of the p53-related proteins: same family, different rules (Q33885465)

29 July 2017

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title

Regulation and function of the p53-related proteins: same family, different rules (English)

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29 July 2017

M A Lohrum

1

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PubMed ID

10754563

29 July 2017

K H Vousden

series ordinal

2

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29 July 2017

1 May 2000

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29 July 2017

Trends in Cell Biology

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29 July 2017

10

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29 July 2017

197-202

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29 July 2017

5

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The role of p53 in tumour suppression: lessons from mouse models

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

The p53 family: same response, different signals?

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

1 reference

7 January 2021

DNA damage enables p73

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p63 is a p53 homologue required for limb and epidermal morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

MDM2 suppresses p73 function without promoting p73 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Identification of a novel p53 functional domain that is necessary for mediating apoptosis

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Mechanisms of p53-mediated apoptosis

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Failure of viral oncoproteins to target the p53-homologue p51A

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Keeping an old friend under control: regulation of p53 stability.

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Regulation of the p53 tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Regulation of p53 stability

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

1 reference

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

SUMO-1 modification activates the transcriptional response of p53

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Role for p300 in stabilization of p53 in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Promoter specificity and stability control of the p53-related protein p73

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Excess beta-catenin promotes accumulation of transcriptionally active p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

MdmX protects p53 from Mdm2-mediated degradation

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

The INK4 family of cell cycle inhibitors in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Identification of a cryptic nucleolar-localization signal in MDM2

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

MDM2 and MDMX bind and stabilize the p53-related protein p73

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Oncogenes and cell death

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

E2F and cell proliferation: a world turned upside down

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Molecular cloning and functional characterization of the upstream promoter region of the human p73 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901736-0

7 January 2021

10.1016/S0962-8924(00)01736-0

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10754563