Kinase inhibitors in cancer therapy: a look ahead (Q33897202)

29 July 2017

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title

Kinase inhibitors in cancer therapy: a look ahead (English)

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29 July 2017

Sedlacek HH

1

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29 July 2017

publication date

1 March 2000

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29 July 2017

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29 July 2017

volume

59

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29 July 2017

issue

3

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29 July 2017

page(s)

435-476

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Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines

29 July 2017

cites work

1 reference

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The prognostic significance of transforming growth factors in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries

21 January 2018

1 reference

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Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

21 January 2018

1 reference

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Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts

21 January 2018

1 reference

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The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Isolation and sequence analysis of a novel human tyrosine kinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

The Fps/Fes Protein-Tyrosine Kinase Promotes Angiogenesis in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Microtubule-based endoplasmic reticulum motility in Xenopus laevis: activation of membrane-associated kinesin during development

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Cytoplasmic to nuclear signal transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Retinoic acid induces changes in c-fgr proto-oncogene mRNA levels in Burkitt's lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00003495-200059030-00004

Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease.

21 January 2018

1 reference

12 December 2020

Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two beta subunits are derived from differences in glycosylation.

1 reference

12 December 2020

Raf-1 kinase, epidermal growth factor receptors, and mutant ras proteins in colonic carcinomas

1 reference

12 December 2020

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro

1 reference

12 December 2020

Evolution, expression, and chromosomal location of a novel receptor tyrosine kinase gene, eph.

1 reference

12 December 2020

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

12 December 2020

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

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12 December 2020

Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients

1 reference

12 December 2020

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

12 December 2020

The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells

1 reference

12 December 2020

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells

1 reference

12 December 2020

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

1 reference

12 December 2020

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

1 reference

12 December 2020

Cyclin E, a potential prognostic marker for breast cancer

1 reference

12 December 2020

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

1 reference

12 December 2020

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

1 reference

12 December 2020

Variables controlling somatomedin production by cultured human fibroblasts

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12 December 2020

Transcripts for transforming growth factors in human breast cancer: clinical correlates

1 reference

12 December 2020

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells

1 reference

12 December 2020

Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy.

1 reference

12 December 2020

MAPK activity is down-regulated in human colon adenocarcinoma: correlation with PKC activity

1 reference

12 December 2020

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation

1 reference

12 December 2020

Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells

1 reference

12 December 2020

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

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12 December 2020

STATs find that hanging together can be stimulating

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12 December 2020

Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells.

1 reference

12 December 2020

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3

1 reference

12 December 2020

The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism.

1 reference

12 December 2020

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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12 December 2020

Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.

1 reference

12 December 2020

Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells

1 reference

12 December 2020

Post-transcriptional regulation of c-fms proto-oncogene expression by dexamethasone and of CSF-1 in human breast carcinomas in vitro

1 reference

12 December 2020

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors

1 reference

12 December 2020

Novel protein kinases expressed in human breast cancer

1 reference

12 December 2020

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1 reference

12 December 2020

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern

1 reference

12 December 2020

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

12 December 2020

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

12 December 2020

The function(s) of CAK, the p34cdc2-activating kinase

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12 December 2020

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1 reference

12 December 2020

Augmented expression of LCK message directed from the downstream promoter in human colorectal cancer specimens

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12 December 2020

Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line

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12 December 2020

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

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12 December 2020

Growth factors and tyrosine kinase receptors during development and cancer

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12 December 2020

Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells

1 reference

12 December 2020

p185neu expression in human lung adenocarcinomas predicts shortened survival

1 reference

12 December 2020

Genistein, a specific inhibitor of tyrosine-specific protein kinases

1 reference

12 December 2020

c-fms is present in primary tumours as well as in their metastases in bone marrow

1 reference

12 December 2020

1 reference

12 December 2020

A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors

1 reference

12 December 2020

Molecular foundations of cancer: New targets for intervention

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12 December 2020

Flg-2, a new member of the family of fibroblast growth factor receptors

1 reference

12 December 2020

Human microvascular endothelial cells express receptors for platelet-derived growth factor

1 reference

12 December 2020

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells.

1 reference

12 December 2020

Epithelial-stromal interactions in basal cell cancer: the PDGF system

1 reference

12 December 2020

c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase

1 reference

12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

12 December 2020

Actions of TNF and INF-γ on Angiogenesis In Vitro

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12 December 2020

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1 reference

12 December 2020

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

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12 December 2020

Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1

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12 December 2020

Selective increase of alternatively spliced Lck transcripts from the proximal promotor in hematopoietic malignancies

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12 December 2020

Tyrosine kinase receptor indistinguishable from the c-met protein

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12 December 2020

Smad6 inhibits signalling by the TGF-beta superfamily

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12 December 2020

A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

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12 December 2020

Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels

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12 December 2020

PI3K: downstream AKTion blocks apoptosis

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12 December 2020

The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells

1 reference

12 December 2020

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

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12 December 2020

Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor

1 reference

12 December 2020

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

1 reference

12 December 2020

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

1 reference

12 December 2020

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

12 December 2020

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

1 reference

12 December 2020

Expression of platelet-derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors

1 reference

12 December 2020

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

1 reference

12 December 2020

Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products

1 reference

12 December 2020

Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest origin

1 reference

12 December 2020

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

1 reference

12 December 2020

Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels

1 reference

12 December 2020

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

1 reference

12 December 2020

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

1 reference

12 December 2020

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy

1 reference

12 December 2020

Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA

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12 December 2020

Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin

1 reference

12 December 2020

Expression of platelet-derived growth factors, transforming growth factors, and the ros gene in a variety of primary human brain tumors

1 reference

12 December 2020

Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors

1 reference

12 December 2020

Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell-matrix interactions

1 reference

12 December 2020

Angiogenic factors stimulate mast-cell migration

1 reference

12 December 2020

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

1 reference

12 December 2020

The alphas, betas, and kinases of cytokine receptor complexes

1 reference

12 December 2020

fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection

1 reference

12 December 2020

Neurofibromatosis type 1 and Ras-mediated signaling: filling in the GAPs.

1 reference

12 December 2020

Inactivation of Smad4 in gastric carcinomas

1 reference

12 December 2020

Correlation of constitutive activation of raf-1 with morphological transformation and abrogation of tyrosine phosphorylation of distinct sets of proteins in human squamous carcinoma cells

1 reference

12 December 2020

Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents.

1 reference

12 December 2020

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

12 December 2020

Metabolism and effects of epidermal growth factor and related growth factors in mammals

1 reference

12 December 2020

The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2.

1 reference

12 December 2020

Signals and genes in the control of cell-cycle progression

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12 December 2020

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

1 reference

12 December 2020

Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase

1 reference

12 December 2020

Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene

1 reference

12 December 2020

Expression and function of IRS-1 in insulin signal transmission.

1 reference

12 December 2020

Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ.

1 reference

12 December 2020

Analysis of oncogene expression in primary human gliomas: evidence for increased expression of the ros oncogene

1 reference

12 December 2020

Expression of cellular oncogenes in human malignancies

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12 December 2020

Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins.

1 reference

12 December 2020

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas

1 reference

12 December 2020

K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation

1 reference

12 December 2020

The retinoblastoma protein and cell cycle control

1 reference

12 December 2020

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

1 reference

12 December 2020

Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation

1 reference

12 December 2020

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1 reference

12 December 2020

Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease

1 reference

12 December 2020

Redundant cyclin overexpression and gene amplification in breast cancer cells

1 reference

12 December 2020

FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro

1 reference

12 December 2020

The retinoblastoma gene family: cousins with overlapping interests

1 reference

12 December 2020

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors

1 reference

12 December 2020

Human chronic lymphocytic leukemia cells regularly express mRNAs of the protooncogenes lck and c-fgr

1 reference

12 December 2020

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222

1 reference

12 December 2020

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin

1 reference

12 December 2020

Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases

1 reference

12 December 2020

Characteristics and distribution of receptors for [D-TRP6]-luteinizing hormone-releasing hormone, somatostatin, epidermal growth factor, and sex steroids in 500 biopsy samples of human breast cancer

1 reference

12 December 2020

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

12 December 2020

Loss of c-kit expression in cultured melanoma cells

1 reference

12 December 2020

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

12 December 2020

Growth factors and their receptors in neoplastic mammary glands

1 reference

12 December 2020

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

12 December 2020

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

1 reference

12 December 2020

Cell cycle control and cancer

1 reference

12 December 2020

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF

1 reference

12 December 2020

The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2.

1 reference

12 December 2020

Cell cycle checkpoints

1 reference

12 December 2020

Novel and known protein tyrosine kinases and their abnormal expression in human melanoma

1 reference

12 December 2020

Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line

1 reference

12 December 2020

Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors

1 reference

12 December 2020

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1 reference

12 December 2020

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability

1 reference

12 December 2020

Stimulation of growth of human breast cancer cells (T47D) by platelet derived growth factor

1 reference

12 December 2020

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells

1 reference

12 December 2020

The phosphorylation connection to cancer (review).

1 reference

12 December 2020

The proto-oncogene c-fms is overexpressed in endometrial cancer

1 reference

12 December 2020

Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate

1 reference

12 December 2020

Hybrid and atypical insulin/insulin-like growth factor I receptors

1 reference

12 December 2020

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.

1 reference

12 December 2020

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors

1 reference

12 December 2020

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1 reference

12 December 2020

Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.

1 reference

12 December 2020

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

1 reference

12 December 2020

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

12 December 2020

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

12 December 2020

Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor.

1 reference

12 December 2020

Cytokines and cell growth control

1 reference

12 December 2020

Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids

1 reference

12 December 2020

Mos and the cell cycle: the molecular basis of the transformed phenotype

1 reference

12 December 2020

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

12 December 2020

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

1 reference

12 December 2020

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

1 reference

12 December 2020

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1 reference

12 December 2020

Focal adhesion kinase pp125FAK is associated with both intercellular junctions and matrix adhesion sites in vivo

1 reference

12 December 2020

Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis.

1 reference

12 December 2020

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1 reference

12 December 2020

Characterization of MEK1 phosphorylation by the v-Mos protein

1 reference

12 December 2020

Expression and function of TRK-B and BDNF in human neuroblastomas

1 reference

12 December 2020

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl

1 reference

12 December 2020

Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma

1 reference

12 December 2020

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

1 reference

12 December 2020

Amplification of c-yes-1 proto-oncogene in a primary human gastric cancer

1 reference

12 December 2020

The biology of vascular endothelial growth factor

1 reference

12 December 2020

TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1 reference

12 December 2020

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1 reference

12 December 2020

MAPKs: new JNK expands the group

1 reference

12 December 2020

Frequency of Smad gene mutations in human cancers.

1 reference

12 December 2020

Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein

1 reference

12 December 2020

Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies

1 reference

12 December 2020

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

1 reference

12 December 2020

Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts

1 reference

12 December 2020

Induction of apoptosis by quercetin: involvement of heat shock protein

1 reference

12 December 2020

Scatter factor induces blood vessel formation in vivo

1 reference

12 December 2020

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1 reference

12 December 2020

Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines.

1 reference

12 December 2020

Paracrine growth regulation of human colon carcinoma organ-specific metastasis

1 reference

12 December 2020

Growth-regulatory factors for normal, premalignant, and malignant human cells in vitro

1 reference

12 December 2020

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

1 reference

12 December 2020

Mutations of ras genes in human tumors (review).

1 reference

12 December 2020

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases

1 reference

12 December 2020

Growth factors in breast cancer

1 reference

12 December 2020

The when and how of Src regulation

1 reference

12 December 2020

cdc2 phosphorylation is required for its interaction with cyclin.

1 reference

12 December 2020

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1 reference

12 December 2020

A biochemical function for ras--at last

1 reference

12 December 2020

Mos oncogene expression in human ovarian tumors

1 reference

12 December 2020

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1 reference

12 December 2020

Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium

1 reference

12 December 2020

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

1 reference

12 December 2020

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors

1 reference

12 December 2020

Human ICE/CED-3 protease nomenclature

1 reference

12 December 2020

Expression of several growth factors and their receptor genes in human colon carcinomas

1 reference

12 December 2020

Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas.

1 reference

12 December 2020

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

12 December 2020

1 reference

12 December 2020

The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q)

1 reference

12 December 2020

Alterations in the expression of pp60c-src and p56lck associated with butyrate-induced differentiation of human colon carcinoma cells

1 reference

12 December 2020

The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.

1 reference

12 December 2020

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

1 reference

12 December 2020

Signal transduction. Feedback from inhibitory SMADs.

1 reference

12 December 2020

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro

1 reference

12 December 2020

The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro

1 reference

12 December 2020

Epidermal growth factor: receptor and ligand expression in human breast cancer.

1 reference

12 December 2020

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

1 reference

12 December 2020

Role of rel family genes in normal and malignant lymphoid cell growth

1 reference

12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

12 December 2020

Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects

1 reference

12 December 2020

Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines

1 reference

12 December 2020

Insulin-like growth factors and breast cancer

1 reference

12 December 2020

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1 reference

12 December 2020

Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases

1 reference

12 December 2020

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1 reference

12 December 2020

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

1 reference

12 December 2020

Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei.

1 reference

12 December 2020

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues

1 reference

12 December 2020

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

12 December 2020

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

1 reference

12 December 2020

Abnormal expression of the MOS proto-oncogene in human thyroid medullary carcinoma

1 reference

12 December 2020

Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities

1 reference

12 December 2020

Autocrine and paracrine roles for growth factors in melanoma.

1 reference

12 December 2020

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

12 December 2020

A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity

1 reference

12 December 2020

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor

1 reference

12 December 2020

Mutational analysis of insulin receptor function: consensus and controversy

1 reference

12 December 2020

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

1 reference

12 December 2020

Expression of c-fgr in EBV positive and negative B cell tumors.

1 reference

12 December 2020

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

12 December 2020

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1 reference

12 December 2020

Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum.

1 reference

12 December 2020

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

1 reference

12 December 2020

Differential induction of 'metabolic genes' after mitogen stimulation and during normal cell cycle progression.

1 reference

12 December 2020

Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density

1 reference

12 December 2020

Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis

1 reference

12 December 2020

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1 reference

12 December 2020

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

1 reference

12 December 2020

T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report

1 reference

12 December 2020

Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein

1 reference

12 December 2020

ras oncogenes in human cancer: a review

1 reference

12 December 2020

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 tran

1 reference

12 December 2020

Transcriptional regulation during the mammalian cell cycle

1 reference

12 December 2020

Vascular permeability factor, an endothelial cell mitogen related to PDGF

1 reference

12 December 2020

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

1 reference

12 December 2020

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer

1 reference

12 December 2020

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

1 reference

12 December 2020

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

12 December 2020

Cultured Kaposi's sarcoma-derived cells express functional PDGF A-type and B-type receptors

1 reference

12 December 2020

Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors

1 reference

12 December 2020

The nuclear tyrosine kinase c-Abl negatively regulates cell growth

1 reference

12 December 2020

Platelet-derived growth factor: mechanism of action and possible in vivo function

1 reference

12 December 2020

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas

1 reference

12 December 2020

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling

1 reference

12 December 2020

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

1 reference

12 December 2020

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

1 reference

12 December 2020

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

1 reference

12 December 2020

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family

1 reference

12 December 2020

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

12 December 2020

Expression of c-fms proto-oncogene product by ovarian cancer cell lines with effects of macrophage colony-stimulating factor on proliferation

1 reference

12 December 2020

Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.

1 reference

12 December 2020

Nucleotide sequence analysis of c-raf-1 cDNA and promoter from a radiation-resistant human squamous carcinoma cell line: deletion within exon 17.

1 reference

12 December 2020

Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25

1 reference

12 December 2020

Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines

1 reference

12 December 2020

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

1 reference

12 December 2020

Expression of platelet-derived growth factor and its receptors in neuroendocrine tumors of the digestive system

1 reference

12 December 2020

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

12 December 2020

Two alternatively spliced forms of the human insulin-like growth factor I receptor have distinct biological activities and internalization kinetics

1 reference

12 December 2020

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas

1 reference

12 December 2020

Vascular endothelial growth factor is a secreted angiogenic mitogen

1 reference

12 December 2020

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1 reference

12 December 2020

Loss of heterozygosity at the c-raf locus in small cell lung carcinoma

1 reference

12 December 2020

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

1 reference

12 December 2020

TGF beta signals through a heteromeric protein kinase receptor complex

1 reference

12 December 2020

pp60c-src activation in human colon carcinoma

1 reference

12 December 2020

C-terminal truncated forms of Met, the hepatocyte growth factor receptor

1 reference

12 December 2020

Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation

1 reference

12 December 2020

Mutational analysis supports a structural model for the cell cycle protein kinase p34

1 reference

12 December 2020

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer

1 reference

12 December 2020

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

12 December 2020

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors

1 reference

12 December 2020

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

1 reference

12 December 2020

Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells

1 reference

12 December 2020

Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation

1 reference

12 December 2020

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation

1 reference

12 December 2020

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines

1 reference

12 December 2020

Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling

1 reference

12 December 2020

Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line

1 reference

12 December 2020

Cultured human endothelial cells express platelet-derived growth factor A chain.

1 reference

12 December 2020

Modulation of c-fms proto-oncogene in an ovarian carcinoma cell line by a hammerhead ribozyme

1 reference

12 December 2020

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

1 reference

12 December 2020

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling

1 reference

12 December 2020

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II

1 reference

12 December 2020

Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

1 reference

12 December 2020

Synthesis of PDGF by cultured human T cells transformed with HTLV-I and II.

1 reference

12 December 2020

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

1 reference

12 December 2020

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

1 reference

12 December 2020

SH2 and SH3 domains: from structure to function

1 reference

12 December 2020

The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines

1 reference

12 December 2020

Signaling by the cytokine receptor superfamily: JAKs and STATs.

1 reference

12 December 2020

Crystal structure of cyclin-dependent kinase 2

1 reference

12 December 2020

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

12 December 2020

Nonreceptor tyrosine protein kinases.

1 reference

12 December 2020

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

12 December 2020

Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles.

1 reference

12 December 2020

The role of the IGF-I receptor in the growth and transformation of mammalian cells.

1 reference

12 December 2020

Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver

1 reference

12 December 2020

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

1 reference

12 December 2020

ret/PTC-1, -2, and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential?

1 reference

12 December 2020

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

12 December 2020

Expression of colony-stimulating factor-1 and its receptor (the protein product of c-fms) in invasive breast tumor cells. Induction of urokinase production via this pathway?

1 reference

12 December 2020

Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes

1 reference

12 December 2020

Sck interacts with KDR and Flt-1 via its SH2 domain

1 reference

12 December 2020

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

12 December 2020

Differential c-myc, c-jun, c-raf and p53 expression in squamous cell carcinoma of the head and neck: implication in drug and radioresistance.

1 reference

12 December 2020

Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines

1 reference

12 December 2020

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1 reference

12 December 2020

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3

1 reference

12 December 2020

Expression of the human T-cell-specific tyrosine kinase YT16 (lck) message in leukemic T-cell lines.

1 reference

12 December 2020

In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells

1 reference

12 December 2020

EGF receptor in neoplasia and metastasis

1 reference

12 December 2020

Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression

1 reference

12 December 2020

Double identity for proteins of the Bcl-2 family

1 reference

12 December 2020

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth

1 reference

12 December 2020

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

1 reference

12 December 2020

Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells

1 reference

12 December 2020

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1 reference

12 December 2020

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase

1 reference

12 December 2020

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases

1 reference

12 December 2020

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

1 reference

12 December 2020

CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB

1 reference

12 December 2020

Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells

1 reference

12 December 2020

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas

1 reference

12 December 2020

Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1

1 reference

12 December 2020

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1 reference

12 December 2020

Insulin-like growth factors and cancer

1 reference

12 December 2020

Actin disruption inhibits bombesin stimulation of focal adhesion kinase (pp125FAK) in prostate carcinoma

1 reference

12 December 2020

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1 reference

12 December 2020

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

1 reference

12 December 2020

Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines

1 reference

12 December 2020

Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity

1 reference

12 December 2020

Involvement of pp60c-src with two major signaling pathways in human breast cancer

1 reference

12 December 2020

Over-expression of lck in Burkitt's lymphoma cell lines

1 reference

12 December 2020

Activation of Raf-1 in human pancreatic adenocarcinoma

1 reference

12 December 2020

Regulation of c-fgr proto-oncogene expression in Burkitt's lymphoma cells: effect of interferon treatment and relationship to EBV status and c-myc mRNA levels

1 reference

12 December 2020

Platelet-derived growth factor in autocrine transformation

1 reference

12 December 2020

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1 reference

12 December 2020

Expression of the sis gene by endothelial cells in culture and in vivo

1 reference

12 December 2020

Detection and partial characterization of receptors for [D-Trp6]-luteinizing hormone-releasing hormone and epidermal growth factor in human endometrial carcinoma

1 reference

12 December 2020

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

1 reference

12 December 2020

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

1 reference

12 December 2020

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

12 December 2020

Molecular characteristics of HGF-SF and its role in cell motility and invasion

1 reference

12 December 2020

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer

1 reference

12 December 2020

Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells

1 reference

12 December 2020

Transforming growth-factor-Beta - a cytokine with multiple actions in oncology and potential clinical-applications (review).

1 reference

12 December 2020

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

1 reference

12 December 2020

A novel NF-kappa B p65 spliced transcript lacking exons 6 and 7 in a non-small cell lung carcinoma cell line

1 reference

12 December 2020

A single point mutation responsible for c-mos polymorphism in cancer patients

1 reference

12 December 2020

Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells

1 reference

12 December 2020

Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells.

1 reference

12 December 2020

Enhancement of experimental colon cancer by genistein.

1 reference

12 December 2020

Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages

1 reference

12 December 2020

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops

1 reference

12 December 2020

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor

1 reference

12 December 2020

Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells

1 reference

12 December 2020

Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor.

1 reference

12 December 2020

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1 reference

12 December 2020

Epidermal growth factor-related peptides and their receptors in human malignancies

1 reference

12 December 2020

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1 reference

12 December 2020

Basic fibroblast growth factor production and growth factor receptors as potential targets for melanoma therapy

1 reference

12 December 2020

Controlling IGF-receptor function: a possible strategy for tumor therapy

1 reference

12 December 2020

Growth factors: regulation of normal and neoplastic growth

1 reference

12 December 2020

Growth factor and peptide receptors in small cell lung cancer

1 reference

12 December 2020

BCR-ABL: an anti-apoptosis gene in chronic myelogenous leukemia.

1 reference

12 December 2020

Clinical and histopathologic evaluation of the expression of Ha‐ras and fes oncogene products in lung cancer

1 reference

12 December 2020

1 reference

12 December 2020

Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation

1 reference

12 December 2020

Expression of messenger RNAs for platelet-derived growth factor and its receptors in human sarcoma cell lines

1 reference

12 December 2020

Catalysis by a multiprotein IkappaB kinase complex

1 reference

12 December 2020

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

1 reference

12 December 2020

Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells

1 reference

12 December 2020

Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia

1 reference

12 December 2020

Growth factors and cancer

1 reference

12 December 2020

Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma

1 reference

12 December 2020

Substrate specificity of CDC2 kinase from human HeLa cells as determined with synthetic peptides and molecular modeling

1 reference

12 December 2020

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

1 reference

12 December 2020

c-Yes tyrosine kinase activity in human colon carcinoma.

1 reference

12 December 2020

Vascular endothelial growth factor induces the disorganization of actin stress fibers accompanied by protein tyrosine phosphorylation and morphological change in Balb/C3T3 cells

1 reference

12 December 2020

Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle

1 reference

12 December 2020

Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines

1 reference

12 December 2020

The c-erb B-2 proto-oncogene in human pancreatic cancer

1 reference

12 December 2020

Transforming growth factor-alpha and endocrine sensitivity in breast cancer

1 reference

12 December 2020

Evidence of autocrine regulation in human hepatoma cell lines

1 reference

12 December 2020

Raf-1 protein expression in human breast cancer cells

1 reference

12 December 2020

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

1 reference

12 December 2020

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells

1 reference

12 December 2020

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

1 reference

12 December 2020

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1 reference

12 December 2020

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

1 reference

12 December 2020

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

12 December 2020

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1 reference

12 December 2020

Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus

1 reference

12 December 2020

1 reference

12 December 2020

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs

1 reference

12 December 2020

CD95 (APO-1/Fas)-associating signalling proteins

1 reference

12 December 2020

An alternative pathway for expression of p56lck from type I promoter transcripts in colon carcinoma

1 reference

12 December 2020

Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer

1 reference

12 December 2020

Activation of protein kinase cascades by osmotic shock

1 reference

12 December 2020

10.2165/00003495-200059030-00004

Identifiers

DOI

1 reference

Dimensions Publication ID

29 July 2017

1047782700

0 references

1 reference