Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. (Q33897793)

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English	Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.	scientific article

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13 February 2020

Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair (English)

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13 February 2020

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13 February 2020

Michael A. Freitas

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13 February 2020

Erich Grotewold

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13 February 2020

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Arti Parihar

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13 February 2020

Frederick A Villamena

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13 February 2020

Liwen Wang

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13 February 2020

Andrea I Doseff

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14 September 2012

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13 February 2020

Biochemical Pharmacology

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13 February 2020

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13 February 2020

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13 February 2020

1571-1580

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13 February 2020

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The DNA damage response and cancer therapy

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Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27.

1 reference

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells

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28 July 2018

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

1 reference

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28 July 2018

Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells

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Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

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ATM signaling and genomic stability in response to DNA damage

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28 July 2018

Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway.

1 reference

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28 July 2018

The Chemopreventive Bioflavonoid Apigenin Modulates Signal Transduction Pathways in Keratinocyte and Colon Carcinoma Cell Lines

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28 July 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin

1 reference

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The many substrates and functions of ATM

1 reference

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The DNA damage response: putting checkpoints in perspective

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Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis

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Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

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29 October 2018

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1 reference

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29 October 2018

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

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29 October 2018

Regulation of cell apoptosis by protein kinase c delta

1 reference

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29 October 2018

Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells.

1 reference

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29 October 2018

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

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1 reference

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Mediterranean diet improves erectile function in subjects with the metabolic syndrome

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Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I

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1 reference

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1 reference

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1 reference

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10.1016/J.BCP.2012.09.005

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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Europe PubMed Central

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13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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