Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection (Q33902324)

29 July 2017

title

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection (English)

1 reference

29 July 2017

Jeremy Juang

1

1 reference

29 July 2017

Peter J R Ebert

2

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29 July 2017

Dan Feng

3

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29 July 2017

K Christopher Garcia

4

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29 July 2017

Michelle Krogsgaard

5

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29 July 2017

Mark M Davis

6

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29 July 2017

language of work or name

English

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publication date

10 May 2010

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29 July 2017

number of pages

12

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Journal of Experimental Medicine

inferred from page(s)

published in

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29 July 2017

volume

207

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29 July 2017

issue

6

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29 July 2017

page(s)

1223-1234

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An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

A constant affinity threshold for T cell tolerance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Polyspecificity of T cell and B cell receptor recognition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

miR-181a is an intrinsic modulator of T cell sensitivity and selection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Constitutive class I-restricted exogenous presentation of self antigens in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

T-cell-receptor affinity and thymocyte positive selection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

T cell receptor antagonist peptides induce positive selection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Positive selection of thymocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Fluorescent probes of cell signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Empty MHC class I molecules come out in the cold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

A T cell receptor-specific blockade of positive selection

28 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Rare, structurally homologous self-peptides promote thymocyte positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Quantitation of peptide anchor residue contributions to class I major histocompatibility complex molecule binding.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882826

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

29 October 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092170

Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex

21 January 2018

1 reference

12 December 2020

Self-nonself discrimination by T cells

1 reference

12 December 2020

Emerging principles for the recognition of peptide antigens by MHC class I molecules

1 reference

12 December 2020

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1 reference

12 December 2020

Tracing interactions of thymocytes with individual stromal cell partners

1 reference

12 December 2020

Identification of a naturally occurring ligand for thymic positive selection

1 reference

12 December 2020

Functional mapping of the orientation for TCR recognition of an H2-Kb-restricted ovalbumin peptide suggests that the beta-chain subunit can dominate the determination of peptide side chain specificity

1 reference

12 December 2020

A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo

1 reference

12 December 2020

Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen

1 reference

12 December 2020

Receptor Sensitivity: When T cells Lose Their Sense of Self

1 reference

12 December 2020

Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells

1 reference

12 December 2020

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

1 reference

12 December 2020

CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20092170

1 reference

29 July 2017

1 reference

29 July 2017

1 reference