Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation (Q33936173)

30 July 2017

Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation (English)

1 reference

30 July 2017

Salt inducible kinase 2

1 reference

Praja ring finger ubiquitin ligase 2

GOA release 2020-03-11

1 reference

Cyclin-dependent kinase 5, regulatory subunit 1 (p35)

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

8

Anne-Claude Gingras

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Nabeel Bardeesy

7

object named as

Nabeel Bardeesy

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author name string

Jun-Ichi Sakamaki

1

1 reference

30 July 2017

Accalia Fu

2

1 reference

30 July 2017

Courtney Reeks

3

1 reference

30 July 2017

Stephen Baird

4

1 reference

30 July 2017

Chantal Depatie

5

1 reference

30 July 2017

Mufida Al Azzabi

6

1 reference

30 July 2017

Nabeel Bardeesy

7

1 reference

30 July 2017

Siu-Pok Yee

9

1 reference

30 July 2017

Robert A Screaton

10

1 reference

30 July 2017

1 March 2014

1 reference

30 July 2017

1 reference

30 July 2017

16

1 reference

30 July 2017

3

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30 July 2017

234-244

1 reference

https://scigraph.springernature.com/pub.10.1038/ncb2919

30 July 2017

0 references

cites work

SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling

1 reference

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CRTC2 is required for β-cell function and proliferation

5 July 2018

1 reference

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Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.

5 July 2018

1 reference

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Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

5 July 2018

1 reference

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Role of AMPK in pancreatic beta cell function.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Cdk5: a multifaceted kinase in neurodegenerative diseases

5 July 2018

1 reference

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Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats

5 July 2018

1 reference

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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

5 July 2018

1 reference

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Cyclin-dependent kinases in brain development and disease

5 July 2018

1 reference

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Type 2 diabetes across generations: from pathophysiology to prevention and management

5 July 2018

1 reference

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Dynamics of insulin secretion and the clinical implications for obesity and diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

A hormone-dependent module regulating energy balance

5 July 2018

1 reference

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Control of PKA stability and signalling by the RING ligase praja2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Downregulation of SIK2 expression promotes the melanogenic program in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

LKB1 regulates pancreatic beta cell size, polarity, and function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Amino acid metabolism, insulin secretion and diabetes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Islet beta cell failure in type 2 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Glucose-sensing mechanisms in pancreatic beta-cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Cdk5-dependent regulation of glucose-stimulated insulin secretion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

The protein kinase complement of the human genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Positional cloning of the mouse obese gene and its human homologue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Metabolic coupling factors in pancreatic beta-cell signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Failure of islet β-cell compensation for insulin resistance causes type 2 diabetes: what causes non-alcoholic fatty liver disease and non-alcoholic steatohepatitis?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

A brain-specific activator of cyclin-dependent kinase 5.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107453

SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24561619

12 December 2020

inferred from PubMed ID database lookup

Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24561619

12 December 2020

inferred from PubMed ID database lookup

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB2919

7 January 2021

inferred from DOI database lookup

Mass spectrometry approaches to study mammalian kinase and phosphatase associated proteins

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB2919

7 January 2021

inferred from DOI database lookup

ProHits: integrated software for mass spectrometry-based interaction proteomics

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB2919

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCB2919

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference