SHP2E76K mutant promotes lung tumorigenesis in transgenic mice (Q34009953)

30 July 2017

title

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice (English)

1 reference

30 July 2017

author name string

Valentina E Schneeberger

1

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30 July 2017

Noreen Luetteke

2

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30 July 2017

Yuan Ren

3

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30 July 2017

Hartmut Berns

4

1 reference

30 July 2017

Liwei Chen

5

1 reference

30 July 2017

Parastou Foroutan

6

1 reference

30 July 2017

Gary V Martinez

7

1 reference

30 July 2017

Eric B Haura

8

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30 July 2017

Jiandong Chen

9

1 reference

30 July 2017

Domenico Coppola

10

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30 July 2017

Jie Wu

11

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30 July 2017

language of work or name

English

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publication date

30 January 2014

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30 July 2017

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30 July 2017

volume

35

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30 July 2017

issue

8

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30 July 2017

page(s)

1717-1725

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KIF5B-RET fusions in lung adenocarcinoma.

30 July 2017

cites work

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RET, ROS1 and ALK fusions in lung cancer

5 July 2018

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Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

5 July 2018

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Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma.

5 July 2018

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SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver

5 July 2018

1 reference

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Critical role of Shp2 in tumor growth involving regulation of c-Myc

5 July 2018

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Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer.

5 July 2018

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Inside the human cancer tyrosine phosphatome

5 July 2018

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Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene

5 July 2018

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Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.

5 July 2018

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Integrative genomic profiling of human prostate cancer

5 July 2018

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Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry

5 July 2018

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Targeting protein tyrosine phosphatases for anticancer drug discovery

5 July 2018

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Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

5 July 2018

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Somatic mutations affect key pathways in lung adenocarcinoma

5 July 2018

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The tyrosine phosphatase Shp2 (PTPN11) in cancer.

5 July 2018

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Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors

5 July 2018

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Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.

5 July 2018

1 reference

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Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

5 July 2018

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Protein tyrosine phosphatases: from genes, to function, to disease

5 July 2018

1 reference

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PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

5 July 2018

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

5 July 2018

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Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange

5 July 2018

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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

5 July 2018

1 reference

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

5 July 2018

1 reference

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

5 July 2018

1 reference

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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

5 July 2018

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Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium

5 July 2018

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

5 July 2018

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Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

5 July 2018

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The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

5 July 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

5 July 2018

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DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

5 July 2018

1 reference

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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

5 July 2018

1 reference

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Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

5 July 2018

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Characterization of Cre-mediated cassette exchange after plasmid microinjection in fertilized mouse oocytes.

5 July 2018

1 reference

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

Crystal structure of the tyrosine phosphatase SHP-2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

Characterization of the chicken beta-globin insulator

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

Association of p120 ras GAP with endocytic components and colocalization with epidermal growth factor (EGF) receptor in response to EGF stimulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

N-terminal sequences contained in the Src homology 2 and 3 domains of p120 GTPase-activating protein are required for full catalytic activity toward Ras.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

Mapping of the p53 and mdm-2 interaction domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123642

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

5 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

Chipping away at the lung cancer genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

Conditional expression of fibroblast growth factor-7 in the developing and mature lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGU025

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGU025

1 reference

30 July 2017

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30 July 2017

1 reference