Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling (Q34011254)

30 July 2017

Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling (English)

1 reference

30 July 2017

0 references

Sabine Fischer

1

1 reference

30 July 2017

Beata Filipek-Gorniok

series ordinal

2

1 reference

30 July 2017

Johan Ledin

series ordinal

3

1 reference

30 July 2017

5 September 2011

1 reference

BMC Developmental Biology

30 July 2017

1 reference

30 July 2017

11

1 reference

30 July 2017

53

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-213x-11-53

30 July 2017

0 references

cites work

Extracellular interactome of the FGF receptor-ligand system: complexities and the relative simplicity of the worm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The function of a Drosophila glypican does not depend entirely on heparan sulfate modification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The molecular diversity of glycosaminoglycans shapes animal development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mice deficient in Ext2 lack heparan sulfate and develop exostoses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulphate proteoglycans: the sweet side of development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Lipoprotein particles are required for Hedgehog and Wingless signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Functions of heparan sulfate proteoglycans in cell signaling during development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Divide et Impera--the midbrain-hindbrain boundary and its organizer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Role of glycosylation in development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Order out of chaos: assembly of ligand binding sites in heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Wingful, an extracellular feedback inhibitor of Wingless

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Fibroblast growth factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Effective targeted gene 'knockdown' in zebrafish

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Patterning of the zebrafish retina by a wave of sonic hedgehog activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Functions of cell surface heparan sulfate proteoglycans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Structural basis for FGF receptor dimerization and activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Matrix proteoglycans: from molecular design to cellular function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Domain structure of heparan sulfates from bovine organs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Coordinate embryonic expression of three zebrafish engrailed genes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Lipoprotein-heparan sulfate interactions in the Hh pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Zebrafish pea3 and erm are general targets of FGF8 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Jaw and branchial arch mutants in zebrafish I: branchial arches.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Genetic analysis of fin formation in the zebrafish, Danio rerio

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mutations affecting development of the zebrafish inner ear and lateral line.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heparan sulfate structure in mice with genetically modified heparan sulfate production

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-213X-11-53

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference