EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing (Q34016908)

30 July 2017

title

EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing (English)

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30 July 2017

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Chandra Sekhar Pedamallu

10

object named as

Chandra Sekhar Pedamallu

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Matthew Meyerson

object named as

Matthew Meyerson

13

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author name string

Joshua M Francis

1

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30 July 2017

Cheng-Zhong Zhang

2

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Cecile L Maire

3

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30 July 2017

Joonil Jung

4

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Veronica E Manzo

5

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Viktor A Adalsteinsson

6

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30 July 2017

Heather Homer

7

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30 July 2017

Sam Haidar

8

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30 July 2017

Brendan Blumenstiel

9

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Azra H Ligon

11

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J Christopher Love

12

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Keith L Ligon

14

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30 July 2017

publication date

3 June 2014

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30 July 2017

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30 July 2017

volume

4

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30 July 2017

issue

8

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30 July 2017

page(s)

956-971

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Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma

30 July 2017

cites work

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5 July 2018

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EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma

5 July 2018

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The somatic genomic landscape of glioblastoma

5 July 2018

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5 July 2018

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5 July 2018

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Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons

5 July 2018

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A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival

5 July 2018

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5 July 2018

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Single-cell paired-end genome sequencing reveals structural variation per cell cycle

5 July 2018

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5 July 2018

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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

5 July 2018

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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

5 July 2018

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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

5 July 2018

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Highly recurrent TERT promoter mutations in human melanoma

5 July 2018

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TERT promoter mutations in familial and sporadic melanoma

5 July 2018

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DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy

5 July 2018

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Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains

5 July 2018

1 reference

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Genome-wide detection of single-nucleotide and copy-number variations of a single human cell

5 July 2018

1 reference

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Evolution of the cancer genome

5 July 2018

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The life history of 21 breast cancers

5 July 2018

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Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors

5 July 2018

1 reference

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Absolute quantification of somatic DNA alterations in human cancer

5 July 2018

1 reference

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

5 July 2018

1 reference

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Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor

5 July 2018

1 reference

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Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm

5 July 2018

1 reference

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Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

5 July 2018

1 reference

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Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies

5 July 2018

1 reference

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Tumour evolution inferred by single-cell sequencing

5 July 2018

1 reference

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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

5 July 2018

1 reference

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

5 July 2018

1 reference

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High-resolution mapping of copy-number alterations with massively parallel sequencing

5 July 2018

1 reference

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

5 July 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

5 July 2018

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An integrated genomic analysis of human glioblastoma multiforme

5 July 2018

1 reference

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

5 July 2018

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected].

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Allelotype of colorectal carcinomas

5 July 2018

1 reference

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Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Structural alterations of the epidermal growth factor receptor gene in human gliomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Somatic mutations of EGFR in colorectal cancers and glioblastomas

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Role of the INK4a locus in tumor suppression and cell mortality.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125473

Epidermal growth factor receptor and Ink4a/Arf

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24893890

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-13-0879

1 reference

30 July 2017

1 reference

30 July 2017

1 reference