Biology-oriented synthesis (Q34061956)

30 July 2017

title

Biology-oriented synthesis (English)

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30 July 2017

4

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30 July 2017

Robin S Bon

2

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Kamal Kumar

object named as

Kamal Kumar

series ordinal

3

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author name string

Stefan Wetzel

series ordinal

1

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30 July 2017

language of work or name

English

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publication date

28 October 2011

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Angewandte Chemie International Edition

30 July 2017

published in

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volume

50

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30 July 2017

issue

46

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30 July 2017

page(s)

10800-10826

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Reverse engineering intracellular biochemical networks.

30 July 2017

cites work

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Cheminformatic Analysis of Natural Products and their Chemical Space

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Scaffold diversity of natural products: inspiration for combinatorial library design

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Small molecules: the missing link in the central dogma

21 January 2018

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The art and practice of structure-based drug design: A molecular modeling perspective

21 January 2018

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Bioactivity-guided navigation of chemical space

21 January 2018

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Virtual ligand screening: strategies, perspectives and limitations

21 January 2018

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Structure-based discovery of antibacterial drugs

21 January 2018

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From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma

21 January 2018

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21 January 2018

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Novel chemical space exploration via natural products

21 January 2018

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Natural products as sources of new drugs over the last 25 years

21 January 2018

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Synthesis of natural product inspired compound collections

21 January 2018

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Biology-inspired synthesis of compound libraries

21 January 2018

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From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

21 January 2018

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Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity

21 January 2018

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Enhancements of screening collections to address areas of unmet medical need: an industry perspective

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Exploring dynamics of protein structure determination and homology-based prediction to estimate the number of superfamilies and folds.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Bioactivity-guided mapping and navigation of chemical space.

21 January 2018

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Erratum: Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

21 January 2018

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

21 January 2018

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A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

21 January 2018

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Signal transducers and activators of transcription as targets for small organic molecules

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201007004

Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Selective estrogen receptor modulation: concept and consequences in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

New pharmacological perspectives and therapeutic potential of PPAR-gamma agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Compound library development guided by protein structure similarity clustering and natural product structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Small-molecule inhibition of APT1 affects Ras localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Principles, implementation, and application of biology-oriented synthesis (BIOS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Identification of protein fold topology shared between different folds inhibited by natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Enantioselective synthesis on the solid phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Synthesis of natural-product-based compound libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Natural products to drugs: natural product derived compounds in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Drug discovery and natural products: end of an era or an endless frontier?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Natural products and combinatorial chemistry: back to the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Stereoselective allylation of aldehydes on solid support and its application in biology-oriented synthesis (BIOS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Stereocomplementary synthesis of a natural product-derived compound collection on a solid phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Biology-Oriented Synthesis of Stereochemically Diverse Natural-Product-Derived Compound Collections by Iterative Allylations on a Solid Support

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

21 January 2018

Chemistry of spiroketals

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Double Stereodifferentiating Aldol Reactions. The Documentation of "Partially Matched" Aldol Bond Constructions in the Assemblage of Polypropionate Systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Asymmetric solid-phase synthesis of 6,6-spiroketals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Natural Product-Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Solid-phase parallel synthesis of natural product-like diaza-bridged heterocycles through Pictet-Spengler intramolecular cyclization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Domino reactions for library synthesis of small molecules in combinatorial chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Wanted: new multicomponent reactions for generating libraries of polycyclic natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Enantioselective Catalysis on the Solid Phase: Synthesis of Natural Product-Derived Tetrahydropyrans Employing the Enantioselective Oxa-Diels–Alder Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

The Ras pathway modulator melophlin A targets dynamins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Synthesis and structure-activity correlation of a brunsvicamide-inspired cyclopeptide collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Solid-Support Based Total Synthesis and Stereochemical Correction of Brunsvicamide A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Total synthesis of chondramide C and its binding mode to F-actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Inhibitors of protein tyrosine phosphatases: next-generation drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

The therapeutic potential of phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Diagnosis and complications of Cushing's syndrome: a consensus statement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Puzzling through fragment-based drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

Fragment-based drug design: how big is too big?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201007004

21 January 2018

Identifiers

DOI

10.1002/ANIE.201007004

1 reference

30 July 2017

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