Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance (Q34068122)

30 July 2017

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance (English)

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30 July 2017

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30 July 2017

Salvatore Fusco

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Emiliano Panieri

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Emiliano Panieri

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author name string

Sofia Chiatamone Ranieri

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30 July 2017

Valentina Labate

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30 July 2017

Marina Mele

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30 July 2017

Valentina Tesori

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30 July 2017

Anna Maria Ferrara

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30 July 2017

Giuseppe Ettore Martorana

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30 July 2017

Tommaso Galeotti

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30 July 2017

Giovambattista Pani

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30 July 2017

language of work or name

English

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publication date

12 July 2010

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

107

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30 July 2017

13420-13425

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30

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

30 July 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

High-resolution imaging of redox signaling in live cells through an oxidation-sensitive yellow fluorescent protein.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

p66Shc-generated oxidative signal promotes fat accumulation

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Genome-wide association studies provide new insights into type 2 diabetes aetiology

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Endocrine regulation of ageing

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Adipocytes as regulators of energy balance and glucose homeostasis

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

TOR pathway: linking nutrient sensing to life span

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Genetics: influence of TOR kinase on lifespan in C. elegans

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Genetics and the specificity of the aging process

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Extended longevity in mice lacking the insulin receptor in adipose tissue

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

The p66shc adaptor protein controls oxidative stress response and life span in mammals

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Molecular links between aging and adipose tissue

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922173

Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance--is insulin resistance initiated in the adipose tissue?

28 October 2018

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12 December 2020

Development of the obese-hyperglycaemic syndrome in mice

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12 December 2020

Bioelectrical impedance analysis for the estimation of body composition in rats

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12 December 2020

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

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12 December 2020

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1008647107

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30 July 2017

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30 July 2017

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