Programming of erythromycin biosynthesis by a modular polyketide synthase (Q34107140)

31 July 2017

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title

Programming of erythromycin biosynthesis by a modular polyketide synthase (English)

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31 July 2017

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David E Cane

1

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31 July 2017

language of work or name

English

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publication date

3 June 2010

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Journal of Biological Chemistry

31 July 2017

published in

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31 July 2017

volume

285

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31 July 2017

issue

36

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31 July 2017

page(s)

27517-27523

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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

31 July 2017

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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An erythromycin analog produced by reprogramming of polyketide synthesis

5 July 2018

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5 July 2018

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5 July 2018

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

5 July 2018

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5 July 2018

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The Biosynthesis of Long-Chain Fatty Acids. Incorporation of Radioactivity from Stereospecifically Tritiated Malonyl Thiol Esters, and the Stereochemistry of the Acetyl-CoA Carboxylase Reaction

5 July 2018

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The Biosynthesis of Long-Chain Fatty Acids. Stereochemical Differentiation in the Enzymic Incorporation of Chiral Acetates

5 July 2018

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Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

5 July 2018

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Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

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The DEBS paradigm for type I modular polyketide synthases and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

A polylinker approach to reductive loop swaps in modular polyketide synthases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

21 January 2018

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Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases

21 January 2018

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Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase

21 January 2018

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Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

21 January 2018

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Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

21 January 2018

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Short-chain dehydrogenases/reductases (SDRs).

21 January 2018

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Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase

21 January 2018

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A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

21 January 2018

1 reference

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Predicting the nature and timing of epimerisation on a modular polyketide synthase

21 January 2018

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Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.144618

The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.R110.144618

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

21 January 2018

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12 December 2020

MACROLIDE STEREOCHEMISTRY. 3. A CONFIGURATIONAL MODEL FOR MACROLIDE ANTIBIOTICS

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12 December 2020

Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates. Preface

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12 December 2020

Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase

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12 December 2020

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

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12 December 2020

Dissecting and exploiting intermodular communication in polyketide synthases

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12 December 2020

Identifiers

DOI

10.1074/JBC.R110.144618

1 reference

31 July 2017

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31 July 2017

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