Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization (Q34115236)

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scientific article published on September 9, 2010

Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization

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English	Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization	scientific article published on September 9, 2010	Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

retracted paper

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Ubiquitin/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Retracted: Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization (English)

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Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization (English)

1 reference

10.1371/JOURNAL.PONE.0012636

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0012636

14 July 2024

Erle S Robertson

2

object named as

Erle S Robertson

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1

object named as

Qiliang Cai

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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publication date

9 September 2010

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Europe PubMed Central

PubMed publication ID

31 July 2017

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012636&type=printable

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20844582

14 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844582/?tool=EBI

online access status

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20844582

14 July 2024

https://europepmc.org/articles/PMC2936558

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20844582

14 July 2024

http://dx.plos.org/10.1371/journal.pone.0012636

1 reference

10.1371/JOURNAL.PONE.0012636

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0012636

14 July 2024

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

9

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Europe PubMed Central

PubMed publication ID

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

9 September 2010

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April 2022 Public Data File from Crossref

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Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Hypoxia signalling in cancer and approaches to enforce tumour regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Ubiquitylation and cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Regulation of ubiquitin ligase dynamics by the nucleolus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

SUMO: a history of modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Function and regulation of cullin-RING ubiquitin ligases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Role of VHL gene mutation in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

HIF-1 and mechanisms of hypoxia sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

The ubiquitin system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Germline mutations in the vhl gene in patients presenting with phaeochromocytomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Mutations of the VHL tumour suppressor gene in renal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 July 2018

Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

Von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

HIF activation by pH-dependent nucleolar sequestration of VHL.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 October 2018

Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936558

28 October 2018

Moving protein heads for breakdown

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012636

21 January 2018

The VHL tumour-suppressor gene paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844582

12 December 2020

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10.1371/JOURNAL.PONE.0012636

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2010PLoSO...512636C

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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