Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease (Q34126315)

31 July 2017

title

Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease (English)

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31 July 2017

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Sara J Tallaksen-Greene

1

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31 July 2017

Anita Janiszewska

2

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31 July 2017

Kasha Benton

3

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31 July 2017

Lech Ruprecht

4

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31 July 2017

Roger L Albin

5

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31 July 2017

language of work or name

English

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publication date

24 July 2010

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31 July 2017

published in

Experimental Neurology

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31 July 2017

volume

225

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31 July 2017

issue

2

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31 July 2017

page(s)

402-407

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Suppression of the intrinsic apoptosis pathway by synaptic activity.

31 July 2017

cites work

1 reference

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Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

5 July 2018

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

5 July 2018

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Coupling of the NMDA receptor to neuroprotective and neurodestructive events

5 July 2018

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5 July 2018

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Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

5 July 2018

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Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

5 July 2018

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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

5 July 2018

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Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism.

5 July 2018

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Rodent genetic models of Huntington disease

5 July 2018

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

5 July 2018

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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

5 July 2018

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Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

5 July 2018

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Trinucleotide Repeat Disorders

5 July 2018

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N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

5 July 2018

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Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity

5 July 2018

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5 July 2018

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N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease

5 July 2018

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Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochlori

5 July 2018

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Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

5 July 2018

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The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.

5 July 2018

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

5 July 2018

1 reference

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Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene

5 July 2018

1 reference

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Mutant huntingtin enhances excitotoxic cell death.

5 July 2018

1 reference

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Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

5 July 2018

1 reference

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The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro

5 July 2018

1 reference

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Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

5 July 2018

1 reference

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Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

5 July 2018

1 reference

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Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

5 July 2018

1 reference

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Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere

5 July 2018

1 reference

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Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

5 July 2018

1 reference

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Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

NMDA receptor function in mouse models of Huntington disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Modulation of [3H]MK-801 binding to NMDA receptors in vivo and in vitro.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939157

Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20659453

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20659453

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EXPNEUROL.2010.07.015

1 reference

31 July 2017

1 reference

31 July 2017

1 reference