Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. (Q34171631)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416059%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

review article

1 reference

title

Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416059%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

Hyun-Jung Kim

series ordinal

1

1 reference

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25 January 2020

Suk-Chul Bae

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416059%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

language of work or name

English

0 references

publication date

26 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416059%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Translational Research

25 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416059%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

3

1 reference

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25 January 2020

page(s)

166-179

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25 January 2020

issue

2

1 reference

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Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma

25 January 2020

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5 July 2018

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5 July 2018

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Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

5 July 2018

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Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer

5 July 2018

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Histone deacetylase inhibitors: molecular mechanisms of action

5 July 2018

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Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

5 July 2018

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5 July 2018

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5 July 2018

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Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies

5 July 2018

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5 July 2018

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Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

5 July 2018

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5 July 2018

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5 July 2018

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Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.

5 July 2018

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Prospects: histone deacetylase inhibitors

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

5 July 2018

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Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor

5 July 2018

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Causal relationship between the loss of RUNX3 expression and gastric cancer

5 July 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

5 July 2018

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

5 July 2018

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Treatment of spinal muscular atrophy by sodium butyrate

5 July 2018

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Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity

5 July 2018

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The human histone deacetylase family

5 July 2018

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Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

5 July 2018

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P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

5 July 2018

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Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

5 July 2018

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Regulation of E2F1 activity by acetylation

5 July 2018

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Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program

5 July 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

5 July 2018

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

5 July 2018

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Extrachromosomal rDNA circles--a cause of aging in yeast

5 July 2018

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Histone acetylation in chromatin structure and transcription

5 July 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

5 July 2018

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DNA methylation and mutation

5 July 2018

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Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

5 July 2018

1 reference

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Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC).

5 July 2018

1 reference

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Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

28 October 2018

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Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

28 October 2018

1 reference

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Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

28 October 2018

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28 October 2018

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Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

28 October 2018

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Increased expression of histone deacetylase 2 is found in human gastric cancer.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Expression profile of histone deacetylase 1 in gastric cancer tissues.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Histone deacetylase inhibitors in cancer therapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056563

Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1

28 October 2018

1 reference

12 December 2020

A phase II study of depsipeptide in refractory metastatic renal cell cancer

1 reference

12 December 2020

Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies

1 reference

12 December 2020

Promising antitumor activity with MGCD0103, a novel isotype-selective histone deacetylase inhibitor

1 reference

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21416059%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference