Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) (Q34211343)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21873431%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) (English)

1 reference

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11 February 2020

0 references

2

1 reference

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11 February 2020

Federico Fogolari

series ordinal

3

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11 February 2020

author name string

Bryan VanSchouwen

series ordinal

1

1 reference

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11 February 2020

Giuseppe Melacini

series ordinal

4

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11 February 2020

language of work or name

English

0 references

publication date

26 August 2011

1 reference

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Journal of Biological Chemistry

11 February 2020

published in

1 reference

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11 February 2020

volume

286

1 reference

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11 February 2020

issue

49

1 reference

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11 February 2020

page(s)

42655-42669

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21873431%20AND%20SRC:MED&resulttype=core&format=json

Tuning protein autoinhibition by domain destabilization

11 February 2020

cites work

1 reference

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Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

28 July 2018

1 reference

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Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Mapping allostery through the covariance analysis of NMR chemical shifts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Dynamics connect substrate recognition to catalysis in protein kinase A

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Enzyme dynamics point to stepwise conformational selection in catalysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Large conformational changes in proteins: signaling and other functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Epac: defining a new mechanism for cAMP action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

The role of dynamic conformational ensembles in biomolecular recognition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Conformational selection or induced fit: a flux description of reaction mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Dynamically driven ligand selectivity in cyclic nucleotide binding domains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Allostery: absence of a change in shape does not imply that allostery is not at play

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Epac: effectors and biological functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Epac and the cardiovascular system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Molecular dynamics: survey of methods for simulating the activity of proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Structural change in response to ligand binding.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Structure and regulation of the cAMP-binding domains of Epac2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Protein flexibility and computer-aided drug design

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Molecular recognition by induced fit: how fit is the concept?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

A family of cAMP-binding proteins that directly activate Rap1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234915

Epac proteins: multi-purpose cAMP targets

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Evolution of allostery in the cyclic nucleotide binding module

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Structural dynamics in the activation of Epac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

The role of dynamics in allosteric regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Selected-fit versus induced-fit protein binding: kinetic differences and mutational analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Parsing partial molar volumes of small molecules: a molecular dynamics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Thermodynamic dissection of the Ezrin FERM/CERMAD interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

BIOCHEMISTRY: How Do Proteins Interact?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Complementarity of Structure Ensembles in Protein-Protein Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.277723

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21873431

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.277723

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21873431%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21873431%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21873431

1 reference