The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. (Q34226618)

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15 January 2020

title

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks (English)

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1

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Hemmo H Meyer

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author name string

Danilo Ritz

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Shreya Paliwal

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Zuzana Garajova

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Matthias Bosshard

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Niels Mailand

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Pavel Janscak

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Ulrich Hübscher

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Kristijan Ramadan

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publication date

23 October 2011

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15 January 2020

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volume

13

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issue

11

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page(s)

1376-1382

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https://scigraph.springernature.com/pub.10.1038/ncb2367

15 January 2020

exact match

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cites work

The DNA-damage response in human biology and disease

1 reference

Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

21 January 2018

1 reference

Crosstalk between histone modifications during the DNA damage response.

21 January 2018

1 reference

Principles of ubiquitin and SUMO modifications in DNA repair.

21 January 2018

1 reference

Regulatory ubiquitylation in response to DNA double-strand breaks

21 January 2018

1 reference

The ubiquitous role of ubiquitin in the DNA damage response

21 January 2018

1 reference

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

1 reference

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

1 reference

ERAD: the long road to destruction

21 January 2018

1 reference

Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

21 January 2018

1 reference

Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase

21 January 2018

1 reference

Insights into adaptor binding to the AAA protein p97.

21 January 2018

1 reference

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

21 January 2018

1 reference

Role(s) of Cdc48/p97 in mitosis.

21 January 2018

1 reference

Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

21 January 2018

1 reference

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

21 January 2018

1 reference

Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.

21 January 2018

1 reference

Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication

21 January 2018

1 reference

VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells

21 January 2018

1 reference

Human MMS21/NSE2 is a SUMO ligase required for DNA repair

21 January 2018

1 reference

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

21 January 2018

1 reference

The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum

21 January 2018

1 reference

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

1 reference

Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells

21 January 2018

1 reference

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

21 January 2018

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

21 January 2018

1 reference

Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.

21 January 2018

1 reference

Critical roles of ring finger protein RNF8 in replication stress responses

21 January 2018

1 reference

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

21 January 2018

1 reference

Ubiquitin networks in cancer

21 January 2018

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Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease

21 January 2018

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Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

21 January 2018

1 reference

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

21 January 2018

1 reference

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

21 January 2018

1 reference

MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

1 reference

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

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Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

21 January 2018

1 reference

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

21 January 2018

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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin

21 January 2018

1 reference

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22020440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ubiquitin signalling in DNA replication and repair

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22020440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22020440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCB2367

1 reference

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Dimensions Publication ID

15 January 2020

0 references

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