AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis. (Q34235694)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22114351%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis (English)

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17 January 2020

3

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17 January 2020

author name string

Rob U Onyenwoke

1

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17 January 2020

Lawrence J Forsberg

2

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17 January 2020

Tyisha Williams

4

1 reference

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17 January 2020

Oscar Alzate

5

1 reference

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17 January 2020

Jay E Brenman

6

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17 January 2020

publication date

23 November 2011

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Molecular Biology of the Cell

17 January 2020

published in

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17 January 2020

volume

23

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17 January 2020

issue

2

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17 January 2020

page(s)

381-389

1 reference

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Understanding protein kinase CK2 mis-regulation upon F508del CFTR expression

17 January 2020

cites work

1 reference

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AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

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A genetic interaction between NDPK and AMPK in Dictyostelium discoideum that affects motility, growth and development.

6 July 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

6 July 2018

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

6 July 2018

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Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila

6 July 2018

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Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase

6 July 2018

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Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

6 July 2018

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Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

6 July 2018

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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

6 July 2018

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

6 July 2018

1 reference

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The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP.

6 July 2018

1 reference

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The mammalian Nm23/NDPK family: from metastasis control to cilia movement

6 July 2018

1 reference

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LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

6 July 2018

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

6 July 2018

1 reference

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Profiling of experience-regulated proteins in the songbird auditory forebrain using quantitative proteomics

6 July 2018

1 reference

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LKB1 and AMPK in cell polarity and division

6 July 2018

1 reference

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Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

6 July 2018

1 reference

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Energy-dependent regulation of cell structure by AMP-activated protein kinase

6 July 2018

1 reference

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LKB1 and AMPK maintain epithelial cell polarity under energetic stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Glucose metabolism and cancer

6 July 2018

1 reference

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Understanding the molecular basis of the interaction between NDPK-A and AMPK alpha 1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

AMP-activated protein kinase--development of the energy sensor concept.

6 July 2018

1 reference

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NDPK-A (but not NDPK-B) and AMPK alpha1 (but not AMPK alpha2) bind the cystic fibrosis transmembrane conductance regulator in epithelial cell membranes.

6 July 2018

1 reference

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

6 July 2018

1 reference

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A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung

6 July 2018

1 reference

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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

6 July 2018

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

6 July 2018

1 reference

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The AMP-activated protein kinase pathway--new players upstream and downstream.

6 July 2018

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

6 July 2018

1 reference

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Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

6 July 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Role of mTOR Signalling in the Control of Translation Initiation and Elongation by Nutrients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

AMP-activated protein kinase: the energy charge hypothesis revisited

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits

6 July 2018

1 reference

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Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase

6 July 2018

1 reference

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Mammalian AMP-activated protein kinase subfamily

6 July 2018

1 reference

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A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase

6 July 2018

1 reference

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The expression of the Drosophila awd gene during normal development and in neoplastic brain tumors caused by lgl mutations.

6 July 2018

1 reference

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A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Investigation of the active site and the conformational stability of nucleoside diphosphate kinase by site-directed mutagenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Nucleoside diphosphate kinase from Escherichia coli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Point mutations in awdKpn which revert the prune/Killer of prune lethal interaction affect conserved residues that are involved in nucleoside diphosphate kinase substrate binding and catalysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Activation of a small GTP-binding protein by nucleoside diphosphate kinase.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Phosphoproteome analysis of Drosophila melanogaster embryos

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Regulation of GLUT4 gene expression during exercise

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Drosophila S6 kinase: a regulator of cell size

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Site-directed mutation of Nm23-H1. Mutations lacking motility suppressive capacity upon transfection are deficient in histidine-dependent protein phosphotransferase pathways in vitro.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Nm23-H1 mutation in neuroblastoma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258181

Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture

28 October 2018

1 reference

12 December 2020

Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A

1 reference

12 December 2020

Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP

1 reference

12 December 2020

Protein kinase CK2 acts as a signal molecule switching between the NDPK-A/AMPK 1 complex and NDPK-B

1 reference

12 December 2020

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.E11-08-0699

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22114351%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22114351%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference